gsk3ba glycogen synthase kinase 3 beta, genome duplicate a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gsk3baprovided by ZNC
Official Full Name: glycogen synthase kinase 3 beta, genome duplicate aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990714-4
See related: Ensembl:ENSDARG00000017803 AllianceGenome:ZFIN:ZDB-GENE-990714-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GSK3; gsk3b; fb68h05; fk80d11; GSK-3[b]; wu:fb68h05; wu:fk80d11
Summary: Predicted to enable beta-catenin binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Acts upstream of or within angiogenesis; heart jogging; and heart looping. Predicted to be located in plasma membrane. Predicted to be part of beta-catenin destruction complex. Predicted to be active in several cellular components, including axon; cytosol; and glutamatergic synapse. Is expressed in ovary and testis. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (9577743..9671325, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (9599706..9693358, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

27-Hydroxycholesterol activates the GSK-3beta/beta-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions.
Title: 27-Hydroxycholesterol activates the GSK-3β/β-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions.
GSK-3beta may participate in regulating protein synthesis via TSC2/mTOR signaling and regulating lipid deposition via beta-catenin in the muscle of zebrafish
Title: GSK-3β at the Crossroads in Regulating Protein Synthesis and Lipid Deposition in Zebrafish.
The results of present study indicated that the inhibition of GSK-3beta promoted the reactive oxygen species (ROS) production via beta-catenin/C/EBPalpha signaling in the spleen of zebrafish, and the balance between ROS and antioxidants could be destroyed by the GSK-3beta/beta-catenin/C/EBPalpha signaling.
Title: The inhibition of GSK-3β promotes the production of reactive oxygen species via β-catenin/C/EBPα signaling in the spleen of zebrafish (Danio rerio).
Both active and inactive forms of Gsk3b mediate the cooperative signaling during angiogenesis in zebrafish embryos.
Title: Glycogen synthase kinase 3 beta in somites plays a role during the angiogenesis of zebrafish embryos.
a novel negative, Gsk3beta-independent control mechanism of beta-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation.
Title: Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation.
The regulatory target of Wnts and Igfs, GSK3beta, is inefficiently inactivated in male fin regenerates compared with females. Pharmacological inhibition of GSK3 in males increases blastemal proliferation and restores regenerative pattern.
Title: Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling.
2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function
Title: 2-O-sulfotransferase regulates Wnt signaling, cell adhesion and cell cycle during zebrafish epiboly.
Data show that GSK-3beta inhibition was sufficient to stimulate MG dedifferentiation and the formation of multipotent retinal progenitors that were capable of differentiating into all major retinal cell types.
Title: Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration.
A newly developed highly active GSK3beta inhibitor AR-534, reduced human TAU phosphorylation in TAU transgenic zebrafish.
Title: A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation.
Gsk3b regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity.
Title: Gsk3beta/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

fk80d11.x1 (e-PCR)
- UniSTS:201553

fb68h05.x1 (e-PCR)
- UniSTS:187347

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tau-protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycogen synthase kinase-3 beta

NP_571456.1

EC 2.7.11.26

XP_009302769.1

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131381.1 → NP_571456.1 glycogen synthase kinase-3 beta

See identical proteins and their annotated locations for NP_571456.1

Status: PROVISIONAL

Source sequence(s)

AJ223502

UniProtKB/TrEMBL

B3DGE7, Q9YH60

Related

ENSDARP00000027785.8, ENSDART00000018228.9

Conserved Domains (2) summary

cd14137
Location:51 → 343

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

pfam00069
Location:56 → 340

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

9577743..9671325 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009304494.3 → XP_009302769.1 glycogen synthase kinase-3 beta isoform X1

UniProtKB/TrEMBL

A0A8M3AVR7

Conserved Domains (2) summary

cd14137
Location:51 → 347

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

pfam00069
Location:56 → 344

Pkinase; Protein kinase domain