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Rgr retinal G protein coupled receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 306307, updated on 11-Apr-2024

Summary

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Official Symbol
Rgrprovided by RGD
Official Full Name
retinal G protein coupled receptorprovided by RGD
Primary source
RGD:1309174
See related
Ensembl:ENSRNOG00000012396 AllianceGenome:RGD:1309174
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to be active in photoreceptor outer segment. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 44. Orthologous to human RGR (retinal G protein coupled receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 1.4) See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (12821858..12836665, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (12801594..12816402, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (14286323..14300972, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene coiled-coil serine-rich protein 2 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC134482323 Neighboring gene leucine-rich repeat, Ig-like and transmembrane domains 1 Neighboring gene leucine-rich repeat, Ig-like and transmembrane domains 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. Morimura H, et al. Nat Genet, 1999 Dec. PMID 10581022
  2. Structure and developmental expression of the mouse RGR opsin gene. Tao L, et al. Mol Vis, 1998 Dec 2. PMID 9841934
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of visible light IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RPE-retinal G protein-coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107299.1 → NP_001100769.1  RPE-retinal G protein-coupled receptor

    See identical proteins and their annotated locations for NP_001100769.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474031
    UniProtKB/TrEMBL
    A6K9I7, D3ZG87
    Related
    ENSRNOP00000017038.3, ENSRNOT00000017038.5
    Conserved Domains (1) summary
    cl18967
    Location:38 → 139
    Csx17_I-U; CRISPR/Cas system-associated protein Csx17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    12821858..12836665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275369.1 → XP_063131439.1  RPE-retinal G protein-coupled receptor isoform X1

  2. XM_039094476.2 → XP_038950404.1  RPE-retinal G protein-coupled receptor isoform X2

    Conserved Domains (1) summary
    cd15072
    Location:17 → 286
    7tmA_Retinal_GPR; retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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