smad1 SMAD family member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: smad1provided by ZNC
Official Full Name: SMAD family member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-991119-8
See related: Ensembl:ENSDARG00000027199 AllianceGenome:ZFIN:ZDB-GENE-991119-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: madh1; fb39h09; sb:eu786; wu:fb39h09; wu:fb97e04
Summary: Enables transcription cis-regulatory region binding activity. Involved in BMP signaling pathway; embryonic pattern specification; and regulation of transcription, DNA-templated. Acts upstream of or within dorsal/ventral pattern formation; myeloid cell development; and negative regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including artery; fin; immature eye; mesoderm; and nervous system. Orthologous to human SMAD1 (SMAD family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (35897043..35929002, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (35165016..35196969, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that interplay of Smad1/5 and MAP kinase signaling system (ERK signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
Title: Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence.
this study uncovers that smad1 and smad9 act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.
Title: Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5.
Title: Smad1 and Smad5 differentially regulate embryonic hematopoiesis.

Submit: New GeneRIF Correction

General gene information

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Markers

G40024 (e-PCR)
- UniSTS:37509

fb97e04.x1 (e-PCR)
- UniSTS:191939

fb97e04.x1 (e-PCR)
- UniSTS:191940

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info
involved_in embryonic pattern specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within myeloid cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mothers against decapentaplegic homolog 1

Names: MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; SMA- and MAD-related protein 1; mothers against DPP homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131356.2 → NP_571431.2 mothers against decapentaplegic homolog 1

Status: VALIDATED

Source sequence(s)

BX276105

UniProtKB/Swiss-Prot

Q9I8V2, Q9PUQ3

UniProtKB/TrEMBL

A0A8M2B756, Q5PQZ2

Related

ENSDARP00000147187.1, ENSDART00000181541.1

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:272 → 472

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

cl25751
Location:110 → 275

DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

35897043..35929002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159965.4 → XP_005160022.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/TrEMBL

Q5PQZ2

Related

ENSDARP00000030150.7, ENSDART00000033566.8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:272 → 472

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

cl25751
Location:110 → 275

DUF4045; Domain of unknown function (DUF4045)