Nisch nischarin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nischprovided by RGD
Official Full Name: nischarinprovided by RGD
Primary source: RGD:1306950
See related: Ensembl:ENSRNOG00000018823 AllianceGenome:RGD:1306950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: I-1; I1R; IR1
Summary: Predicted to enable identical protein binding activity; integrin binding activity; and protein kinase binding activity. Involved in several processes, including glucose metabolic process; norepinephrine secretion; and regulation of GABAergic synaptic transmission. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nucleoplasm. Predicted to be active in cytoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 276.5), Kidney (RPKM 266.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6370809..6407104, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6364370..6400675, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7254372..7290670, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nischarin downregulation attenuates cell injury induced by oxidative stress via Wnt signaling.
Title: Nischarin downregulation attenuates cell injury induced by oxidative stress via Wnt signaling.
Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons.
Title: Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity.
Nischarin might be involved in mediating the process of PI3K/PKB pathway-dependent neuronal apoptosis.
Title: The expression pattern of Nischarin after lipopolysaccharides (LPS)-induced neuroinflammation in rats brain cortex.
The results provide a preliminary survey of the distribution of Nischarin in different regions and cell types in the rat brain.
Title: Nischarin is differentially expressed in rat brain and regulates neuronal migration.
The I(1)imidazoline receptor represents a novel site of action for the cyto/cardio-protective efficacy of TVP1022.
Title: I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline.
Taken together, these data support a role for IAA-RP in modulating synaptic transmission in the hippocampus through activation of I-Rs.
Title: Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors.
Agmatine and imidazoline receptor system may be implicated in ethanol-induced anxiolysis and withdrawal anxiety in rats
Title: Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.
Report biphasic dose-dependent modulation of cardiac parasympathetic activity by moxonidine, an imidazoline I1-receptor agonist.
Title: Biphasic dose-dependent modulation of cardiac parasympathetic activity by moxonidine, an imidazoline I1-receptor agonist.
This is the first evidence in vivo that nischarin plays a critical role in I(1) receptor-mediated pERK1/2 production in the rostral ventrolateral medulla and the subsequent hypotension.
Title: Inhibition of nischarin expression attenuates rilmenidine-evoked hypotension and phosphorylated extracellular signal-regulated kinase 1/2 production in the rostral ventrolateral medulla of rats.
Patch-clamp recordings were made from medium spiny neurons in dorsal striatum slices from the rat brain, and the roles of I1-imidazoline receptors in the modulation of synaptic transmission studied.
Title: Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH143465 (e-PCR)
- UniSTS:232712

BI289970 (e-PCR)
- UniSTS:247064

RH127675 (e-PCR)
- UniSTS:210985

BI282284 (e-PCR)
- UniSTS:249771

BI275177 (e-PCR)
- UniSTS:249568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nischarin

Names: I-1 receptor candidate protein; imidazoline receptor 1; imidazoline receptor I-1; imidazoline-1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376918.1 → NP_001363847.1 nischarin isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6ATD2

Related

ENSRNOP00000097646.1, ENSRNOT00000115386.1

Conserved Domains (3) summary

cd06875
Location:15 → 130

PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected

COG4886
Location:288 → 457

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:290 → 312

LRR_RI; leucine-rich repeat [structural motif]
NM_001409024.1 → NP_001395953.1 nischarin isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I5ZTG9

Related

ENSRNOP00000080638.1, ENSRNOT00000113930.1