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Irf9 interferon regulatory factor 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305896, updated on 5-Mar-2024

Summary

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Official Symbol
Irf9provided by RGD
Official Full Name
interferon regulatory factor 9provided by RGD
Primary source
RGD:1308766
See related
Ensembl:ENSRNOG00000019478 AllianceGenome:RGD:1308766
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Isgf3g
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in nucleus. Biomarker of acute pancreatitis and familial hyperlipidemia. Human ortholog(s) of this gene implicated in immunodeficiency 65. Orthologous to human IRF9 (interferon regulatory factor 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 190.9), Lung (RPKM 147.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33065422..33071881)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29095474..29101924)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34282936..34288981)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 2 Neighboring gene ring finger protein 31 Neighboring gene small ribosomal subunit protein uS19-like Neighboring gene REC8 meiotic recombination protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53. Xue BH, et al. Mol Cell Biochem, 2020 Sep. PMID 32577948
  2. Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury. Liu Y, et al. Dig Dis Sci, 2021 Apr. PMID 32462510
  3. Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin. Jiang DS, et al. Hypertension, 2014 Jan. PMID 24144649
  4. PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats. Wan W, et al. J Cereb Blood Flow Metab, 2019 Jul. PMID 29480757, Free PMC Article
  5. IRF9 Prevents CD8(+) T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. Huber M, et al. J Virol, 2017 Nov 15. PMID 28878077, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53.
    Title: A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53.
  2. study shows that Platelet-derived growth factor receptor-beta/interferon regulatory factor 9/sirtuin 1/NF-kappaB signaling played a role in the vascular smooth muscle cell phenotypic transformation after subarachnoid hemorrhage
    Title: PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats.
  3. IRF9 is a vascular injury-response molecule that promotes VSMC proliferation. IRF9 expression is upregulated during neointima formation.
    Title: Interferon regulatory factor 9 is critical for neointima formation following vascular injury.
  4. IRF9 mediated myocardial reperfusion injury
    Title: Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia/reperfusion injury.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ISGF3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interferon regulatory factor 9
Names
interferon dependent positive acting transcription factor 3 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012041.1 → NP_001012041.1  interferon regulatory factor 9

    See identical proteins and their annotated locations for NP_001012041.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079454
    UniProtKB/TrEMBL
    A0A8I5ZQE9, Q68FP4
    Related
    ENSRNOP00000026364.4, ENSRNOT00000026364.5
    Conserved Domains (2) summary
    pfam00605
    Location:11 → 115
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:210 → 374
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33065422..33071881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093300.2 → XP_038949228.1  interferon regulatory factor 9 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQE9, A6KH21, G3V8J4
    Conserved Domains (2) summary
    pfam00605
    Location:11 → 115
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:210 → 374
    IRF-3; Interferon-regulatory factor 3

  2. XM_008770679.3 → XP_008768901.1  interferon regulatory factor 9 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQE9
    Conserved Domains (2) summary
    pfam00605
    Location:37 → 141
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:236 → 400
    IRF-3; Interferon-regulatory factor 3

  3. XM_063274256.1 → XP_063130326.1  interferon regulatory factor 9 isoform X3

  4. XM_006251974.5 → XP_006252036.1  interferon regulatory factor 9 isoform X2

    See identical proteins and their annotated locations for XP_006252036.1

    UniProtKB/TrEMBL
    A0A8I5ZQE9, A6KH21, G3V8J4
    Conserved Domains (2) summary
    pfam00605
    Location:11 → 115
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:210 → 374
    IRF-3; Interferon-regulatory factor 3

  5. XM_006251975.3 → XP_006252037.1  interferon regulatory factor 9 isoform X2

    See identical proteins and their annotated locations for XP_006252037.1

    UniProtKB/TrEMBL
    A0A8I5ZQE9, A6KH21, G3V8J4
    Conserved Domains (2) summary
    pfam00605
    Location:11 → 115
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:210 → 374
    IRF-3; Interferon-regulatory factor 3
Nucleotide Protein Strain
Heading Accession and Version

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