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pax7a paired box 7a [ Danio rerio (zebrafish) ]

Gene ID: 30587, updated on 27-Mar-2024

Summary

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Official Symbol
pax7aprovided by ZNC
Official Full Name
paired box 7aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-201
See related
Ensembl:ENSDARG00000100398 AllianceGenome:ZFIN:ZDB-GENE-990415-201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within developmental pigmentation; regulation of xanthophore differentiation; and wound healing. Located in nucleus. Is expressed in several structures, including central nervous system; muscle; neural crest; neural tube; and post-vent region. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human PAX7 (paired box 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See pax7a in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (41242974..41373311)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (40652029..40782812)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene mucin-5AC-like Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene parkinson protein 7 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Myocyte Dedifferentiation Drives Extraocular Muscle Regeneration in Adult Zebrafish. Saera-Vila A, et al. Invest Ophthalmol Vis Sci, 2015 Jul. PMID 26230763, Free PMC Article
  2. Oncorhynchus mykiss pax7 sequence variations with comparative analyses against other teleost species. Chapalamadugu KC, et al. Springerplus, 2015. PMID 26090310, Free PMC Article
  3. Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish. Mahalwar P, et al. Science, 2014 Sep 12. PMID 25214630
  4. Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish. Devoto SH, et al. Evol Dev, 2006 Jan-Feb. PMID 16409387, Free PMC Article
  5. Establishing a new animal model for muscle regeneration studies. Pourghadamyari H, et al. Mol Biol Res Commun, 2019 Dec. PMID 32042835, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cells marked by pax7a only or by both pax7a and pax7b enter the wound rapidly and contribute to muscle wound repair, but each behaves differently.
    Title: Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair.
  2. Pax7 is required for adult skeletal muscle repair.
    Title: Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.
  3. Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during development.
    Title: Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during zebrafish development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within developmental pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of xanthophore differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within wound healing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
paired box 7; paired box protein Pax-7a
Names
paired box gene 7a
paired box homeotic gene 7a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131325.2 → NP_571400.1  paired box protein Pax-7a isoform PAX7C

    See identical proteins and their annotated locations for NP_571400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CR759952, CU929421
    UniProtKB/TrEMBL
    A0A0R4IPG1, A0A2R8PYQ9, O57418
    Related
    ENSDARP00000138120.1, ENSDART00000172008.3
    Conserved Domains (3) summary
    cd00131
    Location:34 → 166
    PAX; Paired Box domain
    pfam00046
    Location:223 → 276
    Homeobox; Homeobox domain
    pfam12360
    Location:343 → 386
    Pax7; Paired box protein 7

  2. NM_131332.2 → NP_571407.2  paired box protein Pax-7a isoform PAX7D

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    CR759952, CU929421
    UniProtKB/TrEMBL
    A0A0R4IM38, A0A8N1TUG0
    Related
    ENSDARP00000137008.1, ENSDART00000162157.2
    Conserved Domains (3) summary
    cd00131
    Location:34 → 166
    PAX; Paired Box domain
    pfam00046
    Location:223 → 276
    Homeobox; Homeobox domain
    pfam12360
    Location:343 → 386
    Pax7; Paired box protein 7

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    41242974..41373311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306286.3 → XP_009304561.1  paired box 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B4A0
    Conserved Domains (3) summary
    cd00131
    Location:34 → 161
    PAX; Paired Box domain
    pfam00046
    Location:218 → 271
    Homeobox; Homeobox domain
    pfam12360
    Location:338 → 381
    Pax7; Paired box protein 7

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394827.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    50661..168175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131324.2: Suppressed sequence

    Description
    NM_131324.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_131326.1: Suppressed sequence

    Description
    NM_131326.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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