mef2d myocyte enhancer factor 2d [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mef2dprovided by ZNC
Official Full Name: myocyte enhancer factor 2dprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-164
See related: Ensembl:ENSDARG00000040237 AllianceGenome:ZFIN:ZDB-GENE-990415-164
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fk53b11; wu:fc50h03; wu:fk53b11; zgc:109833; etID309781.16
Summary: Enables transcription cis-regulatory region binding activity. Acts upstream of or within heart formation; positive regulation of transcription by RNA polymerase II; and skeletal muscle myosin thick filament assembly. Predicted to be located in nucleus. Is expressed in several structures, including adaxial cell; brain; fast muscle myoblast; musculature system; and primitive olfactory epithelium. Orthologous to human MEF2D (myocyte enhancer factor 2D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (29076241..29146624, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (29141618..29212001, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mef2 controls skeletal muscle formation after terminal differentiation.
Title: Mef2s are required for thick filament formation in nascent muscle fibres.

Submit: New GeneRIF Correction

General gene information

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Markers

MEF2D (e-PCR)
- UniSTS:205397

fc50h03 (e-PCR)
- UniSTS:189276

G39462 (e-PCR)
- UniSTS:9842

fk53b11.x1 (e-PCR)
- UniSTS:201138

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle myosin thick filament assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myocyte-specific enhancer factor 2D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131317.1 → NP_571392.1 myocyte-specific enhancer factor 2D

See identical proteins and their annotated locations for NP_571392.1

Status: PROVISIONAL

Source sequence(s)

U66570

UniProtKB/TrEMBL

Q98870

Related

ENSDARP00000139550.1, ENSDART00000159814.2

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:96 → 152

HJURP_C; Holliday junction regulator protein family C-terminal repeat