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mef2aa myocyte enhancer factor 2aa [ Danio rerio (zebrafish) ]

Gene ID: 30564, updated on 27-Mar-2024

Summary

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Official Symbol
mef2aaprovided by ZNC
Official Full Name
myocyte enhancer factor 2aaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-163
See related
Ensembl:ENSDARG00000031756 AllianceGenome:ZFIN:ZDB-GENE-990415-163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mef2a; wu:fd19d02; etID309779.18
Summary
Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including myofibril assembly; positive regulation of macromolecule metabolic process; and somitogenesis. Predicted to be located in nucleus. Is expressed in cardiovascular system; myotome; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 18
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (23187493..23361540)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (23198545..23369782)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a Neighboring gene uncharacterized LOC108179979 Neighboring gene core-binding factor subunit beta Neighboring gene uncharacterized LOC103909137 Neighboring gene multiple C2 domains, transmembrane 2a Neighboring gene uncharacterized LOC103909138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mef2 controls skeletal muscle formation after terminal differentiation.
    Title: Mef2s are required for thick filament formation in nascent muscle fibres.
  2. Results suggest that myocyte-specific enhancer factor 2A is essential for cardiac contractility
    Title: Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility.
  3. Results suggest that myocyte enhancer factor 2A is essential for zebrafish posterior somite development.
    Title: Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myofibril assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myocyte enhancer factor 2aa; myocyte-specific enhancer factor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131301.2 → NP_571376.2  myocyte enhancer factor 2aa

    Status: VALIDATED

    Source sequence(s)
    BX323877, EB903808, EH440607, EH466515
    UniProtKB/TrEMBL
    A0A8M1PBS7, Q1LXH6
    Related
    ENSDARP00000116960.1, ENSDART00000148106.3
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    23187493..23361540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467575.1 → XP_021323250.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8M9PF86
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:141 → 196
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  2. XM_021467574.1 → XP_021323249.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/TrEMBL
    A0A8M9PF86
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:141 → 196
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  3. XM_021467576.1 → XP_021323251.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/TrEMBL
    A0A8M9PLW4
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:141 → 196
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  4. XM_021467578.1 → XP_021323253.1  myocyte-specific enhancer factor 2A isoform X6

    UniProtKB/TrEMBL
    A0A8M9P9W4
    Related
    ENSDARP00000157383.1, ENSDART00000181762.1
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  5. XM_021467580.1 → XP_021323255.1  myocyte-specific enhancer factor 2A isoform X8

    UniProtKB/TrEMBL
    A0A8M9PPZ2
    Related
    ENSDARP00000123273.1, ENSDART00000147446.2
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 151
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  6. XM_021467577.1 → XP_021323252.1  myocyte-specific enhancer factor 2A isoform X5

    UniProtKB/TrEMBL
    A0A8M9P0X9
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  7. XM_021467579.1 → XP_021323254.1  myocyte-specific enhancer factor 2A isoform X7

    UniProtKB/TrEMBL
    A0A8M9PF89
    Related
    ENSDARP00000021792.9, ENSDART00000005740.11
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  8. XM_005159042.4 → XP_005159099.1  myocyte-specific enhancer factor 2A isoform X3

    See identical proteins and their annotated locations for XP_005159099.1

    UniProtKB/TrEMBL
    A0A8M2B5Z6
    Related
    ENSDARP00000110624.2, ENSDART00000124818.4
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:142 → 196
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  9. XM_005159044.4 → XP_005159101.1  myocyte-specific enhancer factor 2A isoform X4

    UniProtKB/TrEMBL
    A0A8M2B5M2
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:142 → 196
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

  10. XM_005159045.4 → XP_005159102.1  myocyte-specific enhancer factor 2A isoform X9

    UniProtKB/TrEMBL
    A0A0R4IRM3, A0A8M2B5I3
    Related
    ENSDARP00000139238.1, ENSDART00000171594.2
    Conserved Domains (2) summary
    cd00265
    Location:2 → 78
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:98 → 152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
Nucleotide Protein Strain
Heading Accession and Version

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