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Txk TXK tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 305311, updated on 11-Apr-2024

Summary

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Official Symbol
Txkprovided by RGD
Official Full Name
TXK tyrosine kinaseprovided by RGD
Primary source
RGD:1306481
See related
Ensembl:ENSRNOG00000025925 AllianceGenome:RGD:1306481
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including activation of phospholipase C activity; positive regulation of immune response; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within NK T cell differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human TXK (TXK tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 104.8), Spleen (RPKM 80.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35817270..35873454)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35463369..35519448)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (38029809..38085822)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4, pseudogene 3 Neighboring gene tec protein tyrosine kinase Neighboring gene NIPA-like domain containing 1 Neighboring gene cyclic nucleotide gated channel subunit alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. Kashiwakura J, et al. Biol Pharm Bull, 2002 Jun. PMID 12081135
  2. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. Kashiwakura J, et al. J Exp Med, 1999 Oct 18. PMID 10523612, Free PMC Article
  3. Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. Takeba Y, et al. J Immunol, 2002 Mar 1. PMID 11859127
  4. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. Felices M, et al. J Immunol, 2008 Mar 1. PMID 18292523
  5. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Schaeffer EM, et al. Science, 1999 Apr 23. PMID 10213685

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within NK T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase TXK
NP_001019426.1
XP_038947821.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024255.1 → NP_001019426.1  tyrosine-protein kinase TXK

    See identical proteins and their annotated locations for NP_001019426.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095847
    UniProtKB/TrEMBL
    A0A8I5Y280, Q501W1
    Related
    ENSRNOP00000030643.3, ENSRNOT00000035623.5
    Conserved Domains (4) summary
    cd10398
    Location:142 → 247
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:84 → 138
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)
    pfam07714
    Location:270 → 519
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:265 → 520
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    35817270..35873454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091893.2 → XP_038947821.1  tyrosine-protein kinase TXK isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y280
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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