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G3bp2 G3BP stress granule assembly factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305240, updated on 13-Apr-2024

Summary

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Official Symbol
G3bp2provided by RGD
Official Full Name
G3BP stress granule assembly factor 2provided by RGD
Primary source
RGD:1309571
See related
Ensembl:ENSRNOG00000002433 AllianceGenome:RGD:1309571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309571
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of stress granule assembly and protein homooligomerization. Predicted to be located in cytoplasmic stress granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 367.9), Muscle (RPKM 299.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16216684..16304828)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (15932403..16020555)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17437145..17523254)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene endotoxic shock protective protein U9-ORF-like Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene USO1 vesicle transport factor Neighboring gene small nucleolar RNA U13 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 1 Neighboring gene uncharacterized LOC120096578 Neighboring gene small Cajal body-specific RNA 23 like 2 Neighboring gene Sec61 translocon subunit gamma, pseudogene 2 Neighboring gene cyclin dependent kinase like 2 Neighboring gene odontogenesis associated phosphoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway. Hong HQ, et al. Acta Pharmacol Sin, 2018 Feb. PMID 28816235, Free PMC Article
  2. lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2. Xiao X, et al. IUBMB Life, 2021 Sep. PMID 34060227
  3. Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication. Cristea IM, et al. J Virol, 2010 Jul. PMID 20392851, Free PMC Article
  4. Both G3BP1 and G3BP2 contribute to stress granule formation. Matsuki H, et al. Genes Cells, 2013 Feb. PMID 23279204
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2.
    Title: lncRNA XIST knockdown suppresses hypoxia/reoxygenation (H/R)-induced apoptosis of H9C2 cells by regulating miR-545-3p/G3BP2.
  2. new insight into the functions of G3BP2
    Title: G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway.
  3. Two related proteins found in association with nsP4 at both times of infection, GTPase-activating protein (SH3 domain) binding protein 1 (G3BP1) and G3BP2 were also previously identified as associated with sindbis virus nsP2 and nsP3.
    Title: Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein-binding protein 2
Names
GTPase activating protein (SH3 domain) binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013989.2 → NP_001014011.1  ras GTPase-activating protein-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001014011.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5ZNB2, A0A8I6ABI3, Q6AY21
    Related
    ENSRNOP00000091154.1, ENSRNOT00000094514.1
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:293 → 375
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  2. NM_001401436.1 → NP_001388365.1  ras GTPase-activating protein-binding protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6KKA6, F7F5P9

  3. NM_001401437.1 → NP_001388366.1  ras GTPase-activating protein-binding protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6KKA6, F7F5P9

  4. NM_001401438.1 → NP_001388367.1  ras GTPase-activating protein-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6ABI3, Q6AY21

  5. NM_001401439.1 → NP_001388368.1  ras GTPase-activating protein-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6ABI3, Q6AY21
    Related
    ENSRNOP00000079770.1, ENSRNOT00000117159.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    16216684..16304828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250734.5 → XP_006250796.1  ras GTPase-activating protein-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006250796.1

    UniProtKB/TrEMBL
    A0A8I5ZNB2, A6KKA6, F7F5P9
    Related
    ENSRNOP00000003346.4
    Conserved Domains (3) summary
    COG0724
    Location:319 → 414
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  2. XM_006250736.5 → XP_006250798.1  ras GTPase-activating protein-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006250798.1

    UniProtKB/TrEMBL
    A0A8I5ZNB2, A6KKA6, F7F5P9
    Conserved Domains (3) summary
    COG0724
    Location:319 → 414
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  3. XM_063273059.1 → XP_063129129.1  ras GTPase-activating protein-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ABI3, Q6AY21
Nucleotide Protein Strain
Heading Accession and Version

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