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Rasal2 RAS protein activator like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304893, updated on 3-Apr-2024

Summary

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Official Symbol
Rasal2provided by RGD
Official Full Name
RAS protein activator like 2provided by RGD
Primary source
RGD:1307566
See related
Ensembl:ENSRNOG00000004917 AllianceGenome:RGD:1307566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity and signal transduction. Orthologous to human RASAL2 (RAS protein activator like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 116.9), Lung (RPKM 95.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rasal2 in Genome Data Viewer
Location:
13q22
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (71808740..72102723, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (69279882..69569161, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (74770557..75059298, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene angiopoietin-like 1 Neighboring gene Ral GEF with PH domain and SH3 binding motif 2 Neighboring gene C-type lectin domain containing 20A Neighboring gene testis expressed 35 Neighboring gene serine and arginine rich splicing factor 6, pseudogene 2 Neighboring gene uncharacterized LOC134481517 Neighboring gene RIKEN cDNA 2810025M15 gene like Neighboring gene uncharacterized LOC134481518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein activation cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in response to dietary excess ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein nGAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401195.1 → NP_001388124.1  ras GTPase-activating protein nGAP isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I5ZWM6

  2. NM_001401196.1 → NP_001388125.1  ras GTPase-activating protein nGAP isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    Related
    ENSRNOP00000089478.1, ENSRNOT00000102068.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    71808740..72102723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598813.3 → XP_017454302.1  ras GTPase-activating protein nGAP isoform X2

    UniProtKB/TrEMBL
    A0A8I6ABU3

  2. XM_008769638.4 → XP_008767860.2  ras GTPase-activating protein nGAP isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABU3

  3. XM_039090766.2 → XP_038946694.1  ras GTPase-activating protein nGAP isoform X11

    UniProtKB/TrEMBL
    A0A8I6ABU3
    Conserved Domains (4) summary
    cd04013
    Location:132 → 271
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:262 → 592
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:582 → 1058
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:50 → 190
    PH-like; Pleckstrin homology-like domain

  4. XM_006250066.5 → XP_006250128.1  ras GTPase-activating protein nGAP isoform X6

    UniProtKB/TrEMBL
    A0A8I6ABU3
    Conserved Domains (6) summary
    cd04013
    Location:159 → 298
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:289 → 619
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:282 → 620
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:609 → 1085
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:963 → 1102
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:34 → 217
    PH-like; Pleckstrin homology-like domain

  5. XM_063272346.1 → XP_063128416.1  ras GTPase-activating protein nGAP isoform X7

  6. XM_039090765.2 → XP_038946693.1  ras GTPase-activating protein nGAP isoform X10

    UniProtKB/TrEMBL
    A0A8I6ABU3
    Conserved Domains (4) summary
    cd04013
    Location:138 → 277
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:268 → 598
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:588 → 1064
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:56 → 196
    PH-like; Pleckstrin homology-like domain

  7. XM_063272345.1 → XP_063128415.1  ras GTPase-activating protein nGAP isoform X4

  8. XM_063272344.1 → XP_063128414.1  ras GTPase-activating protein nGAP isoform X3

  9. XM_006250067.5 → XP_006250129.1  ras GTPase-activating protein nGAP isoform X12

    See identical proteins and their annotated locations for XP_006250129.1

    UniProtKB/TrEMBL
    A0A8I6ABU3
    Related
    ENSRNOP00000033372.4
    Conserved Domains (6) summary
    cd04013
    Location:131 → 270
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:261 → 591
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:254 → 592
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:581 → 1057
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:935 → 1074
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:6 → 189
    PH-like; Pleckstrin homology-like domain

  10. XM_039090764.2 → XP_038946692.1  ras GTPase-activating protein nGAP isoform X9

    UniProtKB/TrEMBL
    A0A8I6ABU3
    Conserved Domains (4) summary
    cd04013
    Location:139 → 278
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:269 → 599
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:589 → 1065
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:57 → 197
    PH-like; Pleckstrin homology-like domain

  11. XM_063272347.1 → XP_063128417.1  ras GTPase-activating protein nGAP isoform X8

  12. XM_006250065.4 → XP_006250127.1  ras GTPase-activating protein nGAP isoform X5

    UniProtKB/TrEMBL
    A0A8I6ABU3
    Conserved Domains (6) summary
    cd04013
    Location:162 → 301
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:292 → 622
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:285 → 623
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:612 → 1088
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:966 → 1105
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:37 → 220
    PH-like; Pleckstrin homology-like domain

  13. XM_063272348.1 → XP_063128418.1  ras GTPase-activating protein nGAP isoform X13

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107188.1: Suppressed sequence

    Description
    NM_001107188.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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