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max myc associated factor X [ Danio rerio (zebrafish) ]

Gene ID: 30467, updated on 27-Mar-2024

Summary

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Official Symbol
maxprovided by ZNC
Official Full Name
myc associated factor Xprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-152
See related
Ensembl:ENSDARG00000024844 AllianceGenome:ZFIN:ZDB-GENE-990415-152
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zmax; fa92b04; fb52a04; fb95h11; wu:fa92b04; wu:fb52a04; wu:fb95h11
Summary
Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within determination of ventral identity and hemopoiesis. Part of SMAD protein complex. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (28832760..28842575, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (28929881..28939711, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene RAB15, member RAS oncogene family Neighboring gene farnesyltransferase, CAAX box, subunit beta Neighboring gene solute carrier family 10 member 1 Neighboring gene serine and arginine rich splicing factor 5b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Maternal and embryonic expression of zebrafish lef1. Dorsky RI, et al. Mech Dev, 1999 Aug. PMID 10446273
  2. Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of beta-catenin. Kelly GM, et al. Mech Dev, 1995 Oct. PMID 8562427
  3. Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1. Schreiber-Agus N, et al. Oncogene, 1994 Nov. PMID 7936639
  4. Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo. Ungar AR, et al. Mech Dev, 1995 Aug. PMID 8541205
  5. Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Erter CE, et al. Dev Biol, 1998 Dec 15. PMID 9882476

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within determination of ventral identity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of ventral identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SMAD protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein max

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131220.1 → NP_571295.1  protein max

    See identical proteins and their annotated locations for NP_571295.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066760
    UniProtKB/Swiss-Prot
    P52161
    UniProtKB/TrEMBL
    A0A8M1PBI0, Q6NY29
    Related
    ENSDARP00000111552.2, ENSDART00000129858.4
    Conserved Domains (2) summary
    pfam00010
    Location:24 → 75
    HLH; Helix-loop-helix DNA-binding domain
    cl01090
    Location:81 → 103
    SlyX; SlyX

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    28832760..28842575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160621.4 → XP_005160678.1  protein max isoform X3

    UniProtKB/Swiss-Prot
    P52161
    UniProtKB/TrEMBL
    A0A8M2B7H4, Q5SPG2
    Related
    ENSDARP00000119638.1, ENSDART00000137425.3
    Conserved Domains (2) summary
    pfam00010
    Location:15 → 66
    HLH; Helix-loop-helix DNA-binding domain
    cl01090
    Location:72 → 94
    SlyX; SlyX

  2. XM_005160619.4 → XP_005160676.1  protein max isoform X1

    UniProtKB/Swiss-Prot
    P52161
    UniProtKB/TrEMBL
    A0A8M2B7R2
    Related
    ENSDART00000132119.2
    Conserved Domains (2) summary
    pfam00010
    Location:24 → 80
    HLH; Helix-loop-helix DNA-binding domain
    cl01090
    Location:86 → 108
    SlyX; SlyX

  3. XM_005160620.4 → XP_005160677.1  protein max isoform X2

    See identical proteins and their annotated locations for XP_005160677.1

    UniProtKB/Swiss-Prot
    P52161
    UniProtKB/TrEMBL
    F6NWG4, F6PAS2, Q803J7
    Related
    ENSDARP00000046034.5, ENSDART00000046035.7
    Conserved Domains (2) summary
    pfam00010
    Location:15 → 71
    HLH; Helix-loop-helix DNA-binding domain
    cl01090
    Location:77 → 99
    SlyX; SlyX
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52161.1 GenPept UniProtKB/Swiss-Prot:P52161

Gene LinkOut

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