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Git2 GIT ArfGAP 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304546, updated on 9-Dec-2024

Summary

Official Symbol
Git2provided by RGD
Official Full Name
GIT ArfGAP 2provided by RGD
Primary source
RGD:1359708
See related
EnsemblRapid:ENSRNOG00000001190 AllianceGenome:RGD:1359708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CAT2; CAT-2
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; regulation of signal transduction; and synaptic vesicle recycling. Predicted to act upstream of or within behavioral response to pain. Predicted to be located in nucleoplasm. Predicted to be active in calyx of Held. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 360.4), Lung (RPKM 268.4) and 9 other tissues See more
Orthologs
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Genomic context

See Git2 in Genome Data Viewer
Location:
12q16
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47490350..47531232)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41829717..41872621)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47590110..47630991)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 12 open reading frame 76 Neighboring gene ankyrin repeat domain 13a Neighboring gene uncharacterized LOC102547088 Neighboring gene trichoplein, keratin filament binding Neighboring gene glycolipid transfer protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Clone Names

  • MGC94099

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity  
enables GTPase activator activity  
enables metal ion binding  
enables protein-containing complex binding  
enables small GTPase binding  
Component Evidence Code Pubs
is_active_in calyx of Held  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in presynapse  
is_active_in synapse  

General protein information

Preferred Names
ARF GTPase-activating protein GIT2
Names
ARF GAP GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase-interactor 2
GRK-interacting protein 2
cool-interacting tyrosine-phosphorylated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005553.1NP_001005553.1  ARF GTPase-activating protein GIT2

    See identical proteins and their annotated locations for NP_001005553.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081967
    UniProtKB/Swiss-Prot
    Q66H91
    UniProtKB/TrEMBL
    A0A8L2UM41
    Related
    ENSRNOP00000048331.4, ENSRNOT00000045946.5
    Conserved Domains (6) summary
    sd00045
    Location:137165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637752
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    47490350..47531232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249447.5XP_006249509.1  ARF GTPase-activating protein GIT2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6G6J8
    Conserved Domains (6) summary
    smart00105
    Location:2124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:265293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:587701
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137165
    ANK; ANK repeat [structural motif]
  2. XM_063271361.1XP_063127431.1  ARF GTPase-activating protein GIT2 isoform X12

    UniProtKB/TrEMBL
    A0A8I6G6J8
  3. XM_063271359.1XP_063127429.1  ARF GTPase-activating protein GIT2 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZRU3, A0A8I6G6J8
  4. XM_063271354.1XP_063127424.1  ARF GTPase-activating protein GIT2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2UM41
  5. XM_063271355.1XP_063127425.1  ARF GTPase-activating protein GIT2 isoform X3

    UniProtKB/TrEMBL
    A0A8L2UM41
  6. XM_006249445.5XP_006249507.1  ARF GTPase-activating protein GIT2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A5F6, A0A8L2UM41
    Related
    ENSRNOP00000081139.2, ENSRNOT00000097577.2
    Conserved Domains (7) summary
    smart00105
    Location:2124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:608722
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137165
    ANK; ANK repeat [structural motif]
  7. XM_063271357.1XP_063127427.1  ARF GTPase-activating protein GIT2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6G6J8
    Related
    ENSRNOP00000093537.1, ENSRNOT00000100352.2
  8. XM_006249450.5XP_006249512.1  ARF GTPase-activating protein GIT2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6G6J8
    Related
    ENSRNOP00000080405.1, ENSRNOT00000108942.2
    Conserved Domains (6) summary
    smart00105
    Location:2124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:558672
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137165
    ANK; ANK repeat [structural motif]
  9. XM_006249442.5XP_006249504.1  ARF GTPase-activating protein GIT2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UM41
    Conserved Domains (7) summary
    smart00105
    Location:2124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:265293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637751
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:413477
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137165
    ANK; ANK repeat [structural motif]
  10. XM_063271356.1XP_063127426.1  ARF GTPase-activating protein GIT2 isoform X5

    UniProtKB/TrEMBL
    A0A8L2UM41
  11. XM_063271358.1XP_063127428.1  ARF GTPase-activating protein GIT2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6G6J8
  12. XM_063271360.1XP_063127430.1  ARF GTPase-activating protein GIT2 isoform X10

    UniProtKB/TrEMBL
    A0A8L2UM41
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