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Git2 GIT ArfGAP 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304546, updated on 11-Apr-2024

Summary

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Official Symbol
Git2provided by RGD
Official Full Name
GIT ArfGAP 2provided by RGD
Primary source
RGD:1359708
See related
Ensembl:ENSRNOG00000001190 AllianceGenome:RGD:1359708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CAT2; CAT-2
Summary
Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within behavioral response to pain. Predicted to be located in nucleoplasm. Predicted to be active in calyx of Held. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 360.4), Lung (RPKM 268.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47490350..47531232)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41829717..41872621)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47590110..47630991)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 12 open reading frame 76 Neighboring gene ankyrin repeat domain 13a Neighboring gene uncharacterized LOC102547088 Neighboring gene trichoplein, keratin filament binding Neighboring gene glycolipid transfer protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats. Chadwick W, et al. PLoS One, 2012. PMID 22606319, Free PMC Article
  2. The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells. Gavina M, et al. Biol Cell, 2010 Jan 14. PMID 19912111, Free PMC Article
  3. Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse. Montesinos MS, et al. Neuron, 2015 Dec 2. PMID 26637799, Free PMC Article
  4. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. Bagrodia S, et al. J Biol Chem, 1999 Aug 6. PMID 10428811
  5. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, et al. Nat Neurosci, 2007 Mar. PMID 17310244

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. potentially identified the G protein-coupled receptor/cytoskeletal-associated protein GIT2 as a vital integrator and modulator of the normal aging process
    Title: GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats.
  2. Rat basophilic leukaemia RBL-2H3 cells stably transfected with the chemoattractant receptor expressed both GIT1-p21-activated kinase and GIT2-p21-activated kinase endogenous complexes.
    Title: The GIT-PIX complexes regulate the chemotactic response of rat basophilic leukaemia cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94099

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral response to pain ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ARF GTPase-activating protein GIT2
Names
ARF GAP GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase-interactor 2
GRK-interacting protein 2
cool-interacting tyrosine-phosphorylated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005553.1 → NP_001005553.1  ARF GTPase-activating protein GIT2

    See identical proteins and their annotated locations for NP_001005553.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081967
    UniProtKB/Swiss-Prot
    Q66H91
    UniProtKB/TrEMBL
    A0A8L2UM41
    Related
    ENSRNOP00000048331.3, ENSRNOT00000045946.4
    Conserved Domains (6) summary
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]
    cd08847
    Location:1 → 111
    ArfGap_GIT2; GIT2 GTPase activating protein for Arf
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637 → 752
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    47490350..47531232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249447.5 → XP_006249509.1  ARF GTPase-activating protein GIT2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6G6J8
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:587 → 701
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  2. XM_063271361.1 → XP_063127431.1  ARF GTPase-activating protein GIT2 isoform X12

  3. XM_063271359.1 → XP_063127429.1  ARF GTPase-activating protein GIT2 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZRU3

  4. XM_063271354.1 → XP_063127424.1  ARF GTPase-activating protein GIT2 isoform X2

  5. XM_063271355.1 → XP_063127425.1  ARF GTPase-activating protein GIT2 isoform X3

  6. XM_006249445.5 → XP_006249507.1  ARF GTPase-activating protein GIT2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A5F6, A0A8L2UM41
    Related
    ENSRNOP00000086491.1
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:608 → 722
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:414 → 478
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  7. XM_063271357.1 → XP_063127427.1  ARF GTPase-activating protein GIT2 isoform X6

  8. XM_006249450.5 → XP_006249512.1  ARF GTPase-activating protein GIT2 isoform X11

    UniProtKB/TrEMBL
    A0A8I6G6J8
    Conserved Domains (6) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:266 → 294
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:558 → 672
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  9. XM_006249442.5 → XP_006249504.1  ARF GTPase-activating protein GIT2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2UM41
    Conserved Domains (7) summary
    smart00105
    Location:2 → 124
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    cd00204
    Location:109 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08518
    Location:265 → 293
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:637 → 751
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137 → 229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:413 → 477
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    sd00045
    Location:137 → 165
    ANK; ANK repeat [structural motif]

  10. XM_063271356.1 → XP_063127426.1  ARF GTPase-activating protein GIT2 isoform X5

  11. XM_063271358.1 → XP_063127428.1  ARF GTPase-activating protein GIT2 isoform X7

  12. XM_063271360.1 → XP_063127430.1  ARF GTPase-activating protein GIT2 isoform X10

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H91.1 GenPept UniProtKB/Swiss-Prot:Q66H91

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