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Chst12 carbohydrate sulfotransferase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304322, updated on 11-Apr-2024

Summary

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Official Symbol
Chst12provided by RGD
Official Full Name
carbohydrate sulfotransferase 12provided by RGD
Primary source
RGD:1308214
See related
Ensembl:ENSRNOG00000001252 AllianceGenome:RGD:1308214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chondroitin 4-sulfotransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process and dermatan sulfate biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Biomarker of hypertension. Orthologous to human CHST12 (carbohydrate sulfotransferase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 32.2), Lung (RPKM 23.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19224545..19243012, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14110631..14129099, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16199975..16218404, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene galectin-related inter-fiber protein Neighboring gene uncharacterized LOC120095895 Neighboring gene kinesin family member 19B Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Refined mapping of a hypertension susceptibility locus on rat chromosome 12. Prisco SZ, et al. Hypertension, 2014 Oct. PMID 25001272, Free PMC Article
  2. Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. Hiraoka N, et al. J Biol Chem, 2000 Jun 30. PMID 10781601
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112823

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chondroitin 4-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dermatan sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 12
Names
carbohydrate (chondroitin 4) sulfotransferase 12
NP_001032864.1
XP_006248997.1
XP_006248999.1
XP_017453811.1
XP_038945315.1
XP_063127342.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037775.2 → NP_001032864.1  carbohydrate sulfotransferase 12

    See identical proteins and their annotated locations for NP_001032864.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100096
    UniProtKB/TrEMBL
    A0A8I5ZQK5, Q498S0
    Conserved Domains (1) summary
    pfam03567
    Location:165 → 410
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19224545..19243012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248935.3 → XP_006248997.1  carbohydrate sulfotransferase 12 isoform X1

    See identical proteins and their annotated locations for XP_006248997.1

    UniProtKB/TrEMBL
    A0A8I5ZQK5, Q498S0
    Related
    ENSRNOP00000063932.1, ENSRNOT00000001688.6
    Conserved Domains (1) summary
    pfam03567
    Location:165 → 410
    Sulfotransfer_2; Sulfotransferase family

  2. XM_017598322.3 → XP_017453811.1  carbohydrate sulfotransferase 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQK5, Q498S0
    Related
    ENSRNOP00000089351.1
    Conserved Domains (1) summary
    pfam03567
    Location:165 → 410
    Sulfotransfer_2; Sulfotransferase family

  3. XM_039089387.2 → XP_038945315.1  carbohydrate sulfotransferase 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQK5, Q498S0
    Conserved Domains (1) summary
    pfam03567
    Location:165 → 410
    Sulfotransfer_2; Sulfotransferase family

  4. XM_006248937.4 → XP_006248999.1  carbohydrate sulfotransferase 12 isoform X1

    See identical proteins and their annotated locations for XP_006248999.1

    UniProtKB/TrEMBL
    A0A8I5ZQK5, Q498S0
    Related
    ENSRNOP00000080383.1, ENSRNOT00000103516.1
    Conserved Domains (1) summary
    pfam03567
    Location:165 → 410
    Sulfotransfer_2; Sulfotransferase family

  5. XM_063271272.1 → XP_063127342.1  carbohydrate sulfotransferase 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQK5, Q498S0
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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