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Gbp1 guanylate binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304266, updated on 11-Apr-2024

Summary

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Official Symbol
Gbp1provided by RGD
Official Full Name
guanylate binding protein 1provided by RGD
Primary source
RGD:1311877
See related
Ensembl:ENSRNOG00000068984 AllianceGenome:RGD:1311877
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including Hsp90 protein binding activity; cytoskeletal protein binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; negative regulation of interleukin-2 production; and regulation of signal transduction. Predicted to act upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Predicted to be located in several cellular components, including Golgi apparatus; actin cytoskeleton; and vesicle membrane. Orthologous to human GBP1 (guanylate binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 418.1) and Muscle (RPKM 28.7) See more
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Genomic context

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Location:
2q44
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (234071366..234106012)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (231398136..231432773)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248343334..248423402)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC134485987 Neighboring gene guanylate-binding protein 3-like Neighboring gene guanylate binding protein 3 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal α-helices. Syguda A, et al. FEBS J, 2012 Jul. PMID 22607347
  2. The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis. Wehner M, et al. FEBS J, 2012 Jan. PMID 22059445
  3. How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Ghosh A, et al. Nature, 2006 Mar 2. PMID 16511497
  4. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Prakash B, et al. Nature, 2000 Feb 3. PMID 10676968
  5. Interferon-induced guanylate-binding proteins: mapping of the murine Gbp-1 locus to chromosome 3. Prochazka M, et al. Virology, 1985 Sep. PMID 3927587

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables GMP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adhesion of symbiont to host ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in cytolysis in another organism ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to protozoan ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to protozoan ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pyroptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to vacuole ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in symbiont cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon-induced guanylate-binding protein 1; guanylate-binding protein 1
Names
guanylate binding protein 1, interferon-inducible, 67kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    234071366..234106012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591353.3 → XP_017446842.2  guanylate-binding protein 1

    UniProtKB/TrEMBL
    A0A8I6GE08
    Related
    ENSRNOP00000086405.1
    Conserved Domains (3) summary
    PTZ00121
    Location:439 → 773
    PTZ00121; MAEBL; Provisional
    pfam02263
    Location:20 → 283
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:285 → 581
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_039103866.2 → XP_038959794.1  guanylate-binding protein 1

    UniProtKB/TrEMBL
    A0A8I6GE08
    Conserved Domains (3) summary
    PTZ00121
    Location:439 → 773
    PTZ00121; MAEBL; Provisional
    pfam02263
    Location:20 → 283
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:285 → 581
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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