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Eif4a2 eukaryotic translation initiation factor 4A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303831, updated on 11-Apr-2024

Summary

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Official Symbol
Eif4a2provided by RGD
Official Full Name
eukaryotic translation initiation factor 4A2provided by RGD
Primary source
RGD:1309225
See related
Ensembl:ENSRNOG00000001815 AllianceGenome:RGD:1309225
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and negative regulation of RNA-directed 5'-3' RNA polymerase activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 2426.5), Brain (RPKM 2289.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif4a2 in Genome Data Viewer
Location:
11q23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91268730..91276738, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77764126..77770810, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81373047..81379680, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene replication factor C subunit 4 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene small nucleolar RNA SNORA81 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene cyclin B1 interacting protein 1, pseudogene 4 Neighboring gene H3.3 histone A, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The diverse roles of the eIF4A family: you are the company you keep. Lu WT, et al. Biochem Soc Trans, 2014 Feb. PMID 24450646
  2. Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro. Kyono K, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922617
  3. Intracellular localization and unique conserved sequences of three small nucleolar RNAs. Selvamurugan N, et al. Nucleic Acids Res, 1997 Apr 15. PMID 9092667, Free PMC Article
  4. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765
  5. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94588

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic initiation factor 4A-II
Names
ATP-dependent RNA helicase eIF4A-2
eIF-4A-II
eIF4A-II
eukaryotic translation initiation factor 4A
protein synthesis initiation factor 4AII
NP_001008336.1
XP_006248596.1
XP_006248597.1
XP_063126554.1
XP_063126555.1
XP_063126556.1
XP_063126558.1
XP_063126559.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008335.1 → NP_001008336.1  eukaryotic initiation factor 4A-II

    See identical proteins and their annotated locations for NP_001008336.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085859
    UniProtKB/Swiss-Prot
    Q5RKI1
    UniProtKB/TrEMBL
    A6HFS9, A6JS30
    Related
    ENSRNOP00000074545.2, ENSRNOT00000089294.2
    Conserved Domains (1) summary
    PTZ00424
    Location:21 → 407
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    91268730..91276738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270484.1 → XP_063126554.1  eukaryotic initiation factor 4A-II isoform X1

  2. XM_063270488.1 → XP_063126558.1  eukaryotic initiation factor 4A-II isoform X4

  3. XM_063270485.1 → XP_063126555.1  eukaryotic initiation factor 4A-II isoform X2

    UniProtKB/Swiss-Prot
    Q5RKI1
    UniProtKB/TrEMBL
    A6JS30

  4. XM_006248534.5 → XP_006248596.1  eukaryotic initiation factor 4A-II isoform X1

    See identical proteins and their annotated locations for XP_006248596.1

    UniProtKB/TrEMBL
    A6HFS9
    Conserved Domains (1) summary
    PTZ00424
    Location:9 → 408
    PTZ00424; helicase 45; Provisional

  5. XM_063270486.1 → XP_063126556.1  eukaryotic initiation factor 4A-II isoform X4

  6. XM_006248535.5 → XP_006248597.1  eukaryotic initiation factor 4A-II isoform X3

    See identical proteins and their annotated locations for XP_006248597.1

    UniProtKB/TrEMBL
    A6HFS9
    Conserved Domains (1) summary
    PTZ00424
    Location:9 → 361
    PTZ00424; helicase 45; Provisional

  7. XM_063270489.1 → XP_063126559.1  eukaryotic initiation factor 4A-II isoform X5

RNA

  1. XR_358387.5 RNA Sequence

  2. XR_010055952.1 RNA Sequence

  3. XR_005491022.2 RNA Sequence

  4. XR_358388.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RKI1.1 GenPept UniProtKB/Swiss-Prot:Q5RKI1

Gene LinkOut

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