nras NRAS proto-oncogene, GTPase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrasprovided by ZNC
Official Full Name: NRAS proto-oncogene, GTPaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-166
See related: Ensembl:ENSDARG00000038225 AllianceGenome:ZFIN:ZDB-GENE-990415-166
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj99a10; zras-b1; wu:fj99a10; zgc:100761; etID18709.8
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (11114757..11131696, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (11077052..11093991, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although oncogenic NRAS expression alone was found to be insufficient to promote tumor formation, loss of functional p53 was found to collaborate with NRAS expression in the genesis of melanoma.
Title: Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fj99a10.x1 (e-PCR)
- UniSTS:200462

fc55a12.x1 (e-PCR)
- UniSTS:194072

nras (e-PCR), detects polymorphism
- UniSTS:187007

fc48h02.y1 (e-PCR)
- UniSTS:194002

nras (e-PCR), detects polymorphism
- UniSTS:205555

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTPase NRas

Names: N-ras oncogene p21; neuroblastoma RAS viral (v-ras) oncogene homolog; transforming protein N-Ras

NP_571220.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131145.2 → NP_571220.2 GTPase NRas

Status: VALIDATED

Source sequence(s)

CT027601, CU928015, EH537868

UniProtKB/Swiss-Prot

P79737

UniProtKB/TrEMBL

A0A8M1PBE6, Q6DGD1

Related

ENSDARP00000055741.4, ENSDART00000055742.5

Conserved Domains (1) summary

cd04138
Location:3 → 163

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B