fzd2 frizzled class receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd2provided by ZNC
Official Full Name: frizzled class receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-224
See related: Ensembl:ENSDARG00000054438 AllianceGenome:ZFIN:ZDB-GENE-990415-224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz8; zfz2; zg08; cb383; wu:fb70g09
Summary: Predicted to enable Wnt-activated receptor activity and Wnt-protein binding activity. Acts upstream of or within several processes, including Wnt signaling pathway, calcium modulating pathway; heart development; and sensory epithelium regeneration. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; fin; head; head mesenchyme; and mesoderm. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (31621824..31624176)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (31490110..31492462)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fzd2 are broadly expressed throughout the head, during zebrafish craniofacial development
Title: Expression of five frizzleds during zebrafish craniofacial development.
conserved role of a Wnt5/Fz2 signaling pathway in islet formation during pancreatic development.
Title: Wnt5 signaling in vertebrate pancreas development.
frizzled 8c is a receptor for wnt8
Title: Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U49412 (e-PCR)
- UniSTS:187066

AI545106 (e-PCR)
- UniSTS:206292

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway, calcium modulating pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart jogging	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: frizzled-2

Names: frizzled homolog 2; frizzled homolog 8; fz-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131140.1 → NP_571215.1 frizzled-2 precursor

See identical proteins and their annotated locations for NP_571215.1

Status: PROVISIONAL

Source sequence(s)

AY033592

UniProtKB/TrEMBL

Q90YL7

Related

ENSDARP00000071107.3, ENSDART00000076636.5

Conserved Domains (2) summary

cd07458
Location:37 → 154

CRD_FZ1_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 1

cd15245
Location:219 → 548

7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors