fzd5 frizzled class receptor 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzd5provided by ZNC
Official Full Name: frizzled class receptor 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-218
See related: Ensembl:ENSDARG00000025420 AllianceGenome:ZFIN:ZDB-GENE-990415-218
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fz2; fz8c; zg02; fzd8c
Summary: Enables Wnt-activated receptor activity. Acts upstream of or within animal organ development; negative regulation of canonical Wnt signaling pathway; and non-canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including endoderm; eye; gut; hematopoietic stem cell; and neural plate. Used to study coloboma. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (28232522..28234444)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (28421776..28423698)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IMP Inferred from Mutant Phenotype more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within swim bladder development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: frizzled-5

Names: Fz5; frizzled homolog 2; frizzled homolog 5; frizzled homolog 8c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131134.2 → NP_571209.2 frizzled-5 precursor

See identical proteins and their annotated locations for NP_571209.2

Status: PROVISIONAL

Source sequence(s)

BC163118

UniProtKB/TrEMBL

B3DIG4, B3DIG6, F6NK29

Related

ENSDARP00000036600.4, ENSDART00000031761.5

Conserved Domains (2) summary

cd07456
Location:44 → 163

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

cd15249
Location:235 → 546

7tmF_FZD5; class F frizzled subfamily 5, member of 7-transmembrane G protein-coupled receptors