lpla lipoprotein lipase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lplaprovided by ZNC
Official Full Name: lipoprotein lipase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-139
See related: Ensembl:ENSDARG00000087697 AllianceGenome:ZFIN:ZDB-GENE-990415-139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lpl; fb62e04; fc49b03; wu:fb62e04; wu:fc49b03
Summary: Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Acts upstream of or within definitive hemopoiesis and response to (R)-carnitine. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of chylomicron and very-low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; immature eye; midbrain; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (15624521..15629128)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (15598251..15602858)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc49b03 (e-PCR)
- UniSTS:189242

fb62e04.x1 (e-PCR)
- UniSTS:203391

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables apolipoprotein binding	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoprotein lipase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to (R)-carnitine	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very-low-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chylomicron	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipoprotein lipase

NP_571202.1

EC 3.1.1.34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131127.1 → NP_571202.1 lipoprotein lipase precursor

See identical proteins and their annotated locations for NP_571202.1

Status: PROVISIONAL

Source sequence(s)

BC064296

UniProtKB/TrEMBL

Q6P2U2

Related

ENSDARP00000109101.1, ENSDART00000124868.4

Conserved Domains (3) summary

TIGR03230
Location:52 → 492

lipo_lipase; lipoprotein lipase

cd00707
Location:56 → 353

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cl00011
Location:360 → 484

PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...