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Ssh2 slingshot protein phosphatase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303342, updated on 11-Apr-2024

Summary

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Official Symbol
Ssh2provided by RGD
Official Full Name
slingshot protein phosphatase 2provided by RGD
Primary source
RGD:1309389
See related
Ensembl:ENSRNOG00000014285 AllianceGenome:RGD:1309389
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 163.7), Spleen (RPKM 156.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62555388..62807457)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62057400..62309328)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62702286..62954907, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nuclear speckle splicing regulatory protein 1 Neighboring gene microRNA 423 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene uncharacterized LOC134480826 Neighboring gene uncharacterized LOC120095265 Neighboring gene ankyrin repeat domain 13B Neighboring gene coronin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase. Horita Y, et al. J Biol Chem, 2008 Mar 7. PMID 18171679
  2. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Niwa R, et al. Cell, 2002 Jan 25. PMID 11832213
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both LIMK1-mediated phosphorylation and SSH1/SSH2-mediated dephosphorylation of cofilin/ADF are critical for the migration and invasion of tumor cells
    Title: Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase Slingshot homolog 2
Names
slingshot homolog 2
NP_001100494.1
XP_006246967.1
XP_038941949.1
XP_038941950.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107024.1 → NP_001100494.1  protein phosphatase Slingshot homolog 2

    See identical proteins and their annotated locations for NP_001100494.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I6APG2, A6HGX4, F1M4Q5
    Related
    ENSRNOP00000019410.6, ENSRNOT00000019410.7
    Conserved Domains (3) summary
    cd11652
    Location:10 → 243
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:315 → 450
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:258 → 309
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    62555388..62807457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246905.5 → XP_006246967.1  protein phosphatase Slingshot homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6APG2, A0A8I6ATT8
    Related
    ENSRNOP00000091756.1
    Conserved Domains (3) summary
    cd11652
    Location:3 → 236
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:308 → 443
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:251 → 302
    DEK_C; DEK C terminal domain

  2. XM_039086021.2 → XP_038941949.1  protein phosphatase Slingshot homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APG2
    Conserved Domains (3) summary
    cd11652
    Location:38 → 263
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:332 → 475
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:277 → 329
    DEK_C; DEK C terminal domain

  3. XM_039086022.1 → XP_038941950.1  protein phosphatase Slingshot homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6APG2
    Conserved Domains (3) summary
    cd11652
    Location:4 → 218
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:287 → 430
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:232 → 284
    DEK_C; DEK C terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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