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Traf4 Tnf receptor associated factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303285, updated on 11-Apr-2024

Summary

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Official Symbol
Traf4provided by RGD
Official Full Name
Tnf receptor associated factor 4provided by RGD
Primary source
RGD:1306708
See related
Ensembl:ENSRNOG00000013169 AllianceGenome:RGD:1306708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of protein kinase activity; and regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within respiratory gaseous exchange by respiratory system and respiratory tube development. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human TRAF4 (TNF receptor associated factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 183.1), Kidney (RPKM 164.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Traf4 in Genome Data Viewer
Location:
10q25
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63552251..63558356, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63054169..63060284, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65418688..65424802, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Era-like 12S mitochondrial rRNA chaperone 1 Neighboring gene uncharacterized LOC134480829 Neighboring gene family with sequence similarity 222, member B Neighboring gene NIMA-related kinase 8 Neighboring gene TLC domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration. Rousseau A, et al. PLoS Biol, 2013 Dec. PMID 24311986, Free PMC Article
  2. TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. Shiels H, et al. Am J Pathol, 2000 Aug. PMID 10934170, Free PMC Article
  3. TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. Gu X, et al. Cancer Biol Ther, 2007 Dec. PMID 18087216
  4. Oncogenomics of c-Myc transgenic mice reveal novel regulators of extracellular signaling, angiogenesis and invasion with clinical significance for human lung adenocarcinoma. Ciribilli Y, et al. Oncotarget, 2017 Nov 24. PMID 29254206, Free PMC Article
  5. Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. Li S, et al. Mol Cell Biochem, 2010 May. PMID 19937093

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway.
    Title: TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
  
enables tumor necrosis factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory tube development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of plasma membrane signaling receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TNF receptor-associated factor 4
NP_001100487.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107017.2 → NP_001100487.1  TNF receptor-associated factor 4

    See identical proteins and their annotated locations for NP_001100487.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162047
    UniProtKB/TrEMBL
    A0A8I6AJ00, B1WC90, F7F523
    Related
    ENSRNOP00000018468.4, ENSRNOT00000018468.6
    Conserved Domains (3) summary
    cd03781
    Location:308 → 463
    MATH_TRAF4; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF4 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF4, including the Drosophila protein DTRAF1. TRAF molecules serve as adapter ...
    pfam02176
    Location:210 → 269
    zf-TRAF; TRAF-type zinc finger
    cd16641
    Location:15 → 59
    mRING-HC-C3HC3D_TRAF4; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    63552251..63558356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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