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Dvl2 dishevelled segment polarity protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303251, updated on 13-Apr-2024

Summary

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Gene symbol
Dvl2
Gene description
dishevelled segment polarity protein 2
See related
Ensembl:ENSRNOG00000017915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dvl-2
Expression
Biased expression in Thymus (RPKM 78.4), Lung (RPKM 61.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55222245..55231506)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54723356..54732823)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56609810..56619269)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein Neighboring gene PHD finger protein 23 Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene discs large MAGUK scaffold protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression. Cao Y, et al. Eur Rev Med Pharmacol Sci, 2021 Jan. PMID 33577018
  2. Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-κB pathway. Liu XZ, et al. Oncotarget, 2017 Feb 21. PMID 28187436, Free PMC Article
  3. Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Kordes C, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18158920
  4. Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. González-Sancho JM, et al. J Biol Chem, 2013 Mar 29. PMID 23396967, Free PMC Article
  5. The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy. Ma B, et al. J Biol Chem, 2015 May 8. PMID 25825496, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression.
    Title: MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression.
  2. Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
    Title: Dishevelled2 promotes apoptosis and inhibits inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through crosstalk with the NF-κB pathway.
  3. Dpr1 promotes the ubiquitination of Dvl2 by pVHL and mediates the protein aggregate-elicited autophagy initiation
    Title: The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.
  4. Wnt-induced dishevelled 2 phosphorylation has effects in in canonical and noncanonical Wnt3a and Wnt5a signaling
    Title: Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172056.1 → NP_001165527.1  segment polarity protein dishevelled homolog DVL-2

    See identical proteins and their annotated locations for NP_001165527.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HG06, D3ZB71
    Related
    ENSRNOP00000024348.5, ENSRNOT00000024348.7
    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:265 → 352
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:424 → 507
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123 → 263
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:515 → 726
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55222245..55231506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246715.5 → XP_006246777.1  segment polarity protein dishevelled homolog DVL-2 isoform X1

    Conserved Domains (5) summary
    smart00021
    Location:13 → 93
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:261 → 348
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:420 → 503
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:123 → 259
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:511 → 722
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
Nucleotide Protein Strain
Heading Accession and Version

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