wnt10b wingless-type MMTV integration site family, member 10b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wnt10bprovided by ZNC
Official Full Name: wingless-type MMTV integration site family, member 10bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-524
See related: Ensembl:ENSDARG00000040925 AllianceGenome:ZFIN:ZDB-GENE-980526-524
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wnt[d]; Zwnt[d]; wnt10br
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within midbrain-hindbrain boundary development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system; neural plate; neural rod; and neural tube. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (27641471..27647747, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (27714930..27721206, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors results showed that Wnt10b participates in regulating fatty acid synthesis via beta-catenin, C/EBPalpha (CCAAT/enhancer binding protein alpha) and PPARgamma (peroxisome proliferators-activated receptor gamma) in the muscle of zebrafish.
Title: Wnt10b Participates in Regulating Fatty Acid Synthesis in the Muscle of Zebrafish.
In the zebrafish, wnt1 and its neighboring paralog, wnt10b, are expressed in largely overlapping patterns, suggesting co-regulation; results suggest that the control of wnt1 and wnt10b expression is under complex regulation involving the interaction of multiple enhancers.
Title: Analysis of the wnt1 regulatory chromosomal landscape.
In zebrafish embryos lacking Wnt3a, Wnt1 and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 is not maintained after mid-somitogenesis
Title: Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formation.

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General gene information

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Markers

wnt10b (e-PCR), detects polymorphism
- UniSTS:187051

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within midbrain-hindbrain boundary development	IGI Inferred from Genetic Interaction more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-10b

Names: wnt-d; wnt10b-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.