U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fbxw11 F-box and WD repeat domain containing 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303024, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Fbxw11provided by RGD
Official Full Name
F-box and WD repeat domain containing 11provided by RGD
Primary source
RGD:1309121
See related
Ensembl:ENSRNOG00000004395 AllianceGenome:RGD:1309121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dynein complex binding activity; microtubule plus-end binding activity; and ubiquitin-protein transferase activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; regulation of transcription, DNA-templated; and transport along microtubule. Predicted to be located in centrosome; cytosol; and nucleus. Predicted to be part of SCF ubiquitin ligase complex and microtubule associated complex. Predicted to be active in several cellular components, including cytoplasmic microtubule; kinetochore; and neuronal cell body. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 175.6), Brain (RPKM 156.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (17737181..17834834)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (17232735..17330574)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (17542374..17640718)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 10 Neighboring gene uncharacterized LOC120095062 Neighboring gene uncharacterized LOC120095061 Neighboring gene small integral membrane protein 23 Neighboring gene uncharacterized LOC120095064 Neighboring gene uncharacterized LOC134480660

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. Bhatia N, et al. Oncogene, 2002 Feb 28. PMID 11896578
  2. The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. Ohsaki K, et al. J Biochem, 2008 Nov. PMID 18782782
  3. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Peschiaroli A, et al. Mol Cell, 2006 Aug 4. PMID 16885022
  4. Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling. Seo E, et al. Cell Signal, 2009 Jan. PMID 18929646, Free PMC Article
  5. Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Cohen S, et al. Mol Cell Biol, 2004 Jan. PMID 14673179, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in brain morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
F-box/WD repeat-containing protein 11
Names
F-box and WD-40 domain protein 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395595.3 → NP_001382524.1  F-box/WD repeat-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JVE0
    Conserved Domains (4) summary
    cd00200
    Location:261 → 539
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:264 → 299
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:99 → 137
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:141 → 188
    F-box-like

  2. NM_001395596.3 → NP_001382525.1  F-box/WD repeat-containing protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JVE0, A0A8I6GMC9
    Related
    ENSRNOP00000097046.1, ENSRNOT00000118897.1
    Conserved Domains (4) summary
    cd00200
    Location:206 → 484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:209 → 244
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:44 → 82
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:86 → 133
    F-box-like

  3. NM_001414338.2 → NP_001401267.1  F-box/WD repeat-containing protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    17737181..17834834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597240.3 → XP_017452729.1  F-box/WD repeat-containing protein 11 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JVE0

  2. XM_017597241.3 → XP_017452730.1  F-box/WD repeat-containing protein 11 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JVE0
    Conserved Domains (4) summary
    cd00200
    Location:227 → 505
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:230 → 265
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:65 → 103
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:107 → 154
    F-box-like

  3. XM_039085889.2 → XP_038941817.1  F-box/WD repeat-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JVE0, A0A8I6GIW9
    Related
    ENSRNOP00000091319.1
    Conserved Domains (4) summary
    cd00200
    Location:264 → 542
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:267 → 302
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:102 → 140
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:144 → 191
    F-box-like

  4. XM_017597238.3 → XP_017452727.1  F-box/WD repeat-containing protein 11 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JVE0

  5. XM_039085890.2 → XP_038941818.1  F-box/WD repeat-containing protein 11 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZPA1, A0A8I5ZUE3
    Related
    ENSRNOP00000079990.1
    Conserved Domains (4) summary
    cd00200
    Location:208 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211 → 246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:46 → 84
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88 → 135
    F-box-like

  6. XM_017597243.3 → XP_017452732.1  F-box/WD repeat-containing protein 11 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JVE0, D3ZXC6
    Related
    ENSRNOP00000059948.2

  7. XM_017597244.3 → XP_017452733.1  F-box/WD repeat-containing protein 11 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JVE0
    Related
    ENSRNOP00000069447.2
    Conserved Domains (4) summary
    cd00200
    Location:208 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211 → 246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:46 → 84
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88 → 135
    F-box-like

  8. XM_063268958.1 → XP_063125028.1  F-box/WD repeat-containing protein 11 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106993.1: Suppressed sequence

    Description
    NM_001106993.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous