jak2b Janus kinase 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jak2bprovided by ZNC
Official Full Name: Janus kinase 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-123
See related: Ensembl:ENSDARG00000018882 AllianceGenome:ZFIN:ZDB-GENE-980526-123
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jak2; JAK2bCA
Summary: Predicted to enable ATP binding activity; histone binding activity; and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in erythrocyte differentiation. Predicted to act upstream of or within chromatin organization; intracellular signal transduction; and protein phosphorylation. Predicted to be located in several cellular components, including cytoskeleton; endomembrane system; and nucleus. Is expressed in several structures, including lateral line; lens; mandibular arch skeleton; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (66043820..66118416)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (65364705..65439304)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma signal.
Title: In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase JAK2

Names: Jak2b kinase; PTK JAK2b; protein tyrosine kinase JAK2b

NP_571162.1

EC 2.7.1.112

EC 2.7.10.2

XP_017211527.1

EC 2.7.1.112

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131087.1 → NP_571162.1 tyrosine-protein kinase JAK2

See identical proteins and their annotated locations for NP_571162.1

Status: PROVISIONAL

Source sequence(s)

DQ408763

UniProtKB/TrEMBL

C0RW38

Related

ENSDARP00000028132.9, ENSDART00000016019.9

Conserved Domains (7) summary

smart00219
Location:834 → 1104

TyrKc; Tyrosine kinase, catalytic domain

cd10379
Location:370 → 466

SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins

smart00295
Location:29 → 262

B41; Band 4.1 homologues

cd13333
Location:258 → 370

FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2

cd14473
Location:144 → 253

FERM_B-lobe; FERM domain B-lobe

pfam07714
Location:528 → 790

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:829 → 1112

PKc_like; Protein Kinases, catalytic domain