Sat1 spermidine/spermine N1-acetyl transferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sat1provided by RGD
Official Full Name: spermidine/spermine N1-acetyl transferase 1provided by RGD
Primary source: RGD:1586174
See related: Ensembl:ENSRNOG00000003809 AllianceGenome:RGD:1586174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sat; SSAT; Ab2-402
Summary: Enables N-acetyltransferase activity and spermidine binding activity. Involved in polyamine catabolic process and spermidine acetylation. Located in cytosol. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 841.9), Kidney (RPKM 672.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (44008089..44011376)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (40158354..40161641)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (43626480..43629767)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results indicate that both isoforms are expressed in MNTB principal neurons, and demonstrate that functional system A transporters are present in the plasma membrane of neurons.
Title: Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons.
Sat-1 preferentially works as an electroneutral sulfate-bicarbonate or oxalate-bicarbonate exchanger.
Title: Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions.
These results suggest that myocardial SSAT is induced by AMPK signaling and function as a cardioprotectant under ATP-depleted conditions.
Title: Myocardial SSAT induction via AMPK signaling and its implication for ischemic injury.
SSAT has a role in kidney ischemia-reperfusion injury
Title: Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury.

Submit: New GeneRIF Correction

General gene information

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Markers

Sat1 (e-PCR), detects polymorphism
- UniSTS:531487

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables diamine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables spermidine binding	IBA Inferred from Biological aspect of Ancestor more info
enables spermidine binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in polyamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in polyamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in polyamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in putrescine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in spermidine acetylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine acetylation	ISO Inferred from Sequence Orthology more info
involved_in spermine acetylation	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: diamine acetyltransferase 1

Names: Spermidine / spermine N1-acyltransferase (diamine acetyltransferase); diamine N-acetyltransferase 1

NP_001007668.1

EC 2.3.1.57

XP_038955574.1

EC 2.3.1.57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007667.3 → NP_001007668.1 diamine acetyltransferase 1

See identical proteins and their annotated locations for NP_001007668.1

Status: VALIDATED

Source sequence(s)

BC060588

UniProtKB/TrEMBL

A6IPR5, D3ZFF5, Q6P9U6

Related

ENSRNOP00000068531.1, ENSRNOT00000086311.2

Conserved Domains (1) summary

pfam00583
Location:36 → 144

Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

44008089..44011376

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099646.2 → XP_038955574.1 diamine acetyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8J8XCW9, A6IPS0

Conserved Domains (1) summary

pfam00583
Location:4 → 69

Acetyltransf_1; Acetyltransferase (GNAT) family