ins preproinsulin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: insprovided by ZNC
Official Full Name: preproinsulinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-110
See related: Ensembl:ENSDARG00000035350 AllianceGenome:ZFIN:ZDB-GENE-980526-110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:109842
Summary: Predicted to enable hormone activity. Acts upstream of or within several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (37854695..37857689)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (37254542..37257536)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sing glucose as a disease-relevant readout, we screened 2233 molecules and identified three that consistently reduced glucose levels in insulin mutants. Most significantly, we uncovered an insulin-independent beneficial role for androgen receptor antagonism in hyperglycemia, mostly by reducing fasting glucose levels.
Title: Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
Title: Early developmental expression of two insulins in zebrafish (Danio rerio).
These findings suggest that GHRL regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor in the central nervous system and partly involved in carbohydrate-glycogen metabolism.
Title: Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
Title: Insulin expression in the brain and pituitary cells of tilapia (Oreochromis niloticus).

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General gene information

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Markers

ins (e-PCR), detects polymorphism
- UniSTS:205592

fd05a10 (e-PCR)
- UniSTS:204694

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of pancreatic A cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to glucose	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within type B pancreatic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin

Names: insa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131056.1 → NP_571131.1 insulin preproprotein

See identical proteins and their annotated locations for NP_571131.1

Status: VALIDATED

Source sequence(s)

AF036326

UniProtKB/Swiss-Prot

O73727, Q504H9

UniProtKB/TrEMBL

B2GSI0

Related

ENSDARP00000051221.5, ENSDART00000051222.6

Conserved Domains (1) summary

cd04367
Location:25 → 108

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...