Lpar4 lysophosphatidic acid receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lpar4provided by RGD
Official Full Name: lysophosphatidic acid receptor 4provided by RGD
Primary source: RGD:1563686
See related: Ensembl:ENSRNOG00000002428 AllianceGenome:RGD:1563686
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr23; RGD1563686
Summary: Predicted to enable lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to be located in nuclear body and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 24.0), Heart (RPKM 21.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (76106319..76119807)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (72033486..72046978)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (78042859..78056347)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BI294122 (e-PCR)
- UniSTS:246050

RH131472 (e-PCR)
- UniSTS:214755

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lysophosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 4

Names: G protein-coupled receptor 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106940.1 → NP_001100410.1 lysophosphatidic acid receptor 4

See identical proteins and their annotated locations for NP_001100410.1

Status: PROVISIONAL

Source sequence(s)

CH473969

UniProtKB/TrEMBL

A6IV57, D3ZHA3

Related

ENSRNOP00000003286.5, ENSRNOT00000003286.7

Conserved Domains (1) summary

cd15155
Location:40 → 322

7tmA_LPAR4; lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors