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Gpr174 G protein-coupled receptor 174 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302373, updated on 11-Apr-2024

Summary

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Official Symbol
Gpr174provided by RGD
Official Full Name
G protein-coupled receptor 174provided by RGD
Primary source
RGD:1564689
See related
Ensembl:ENSRNOG00000032970 AllianceGenome:RGD:1564689
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564689
Summary
Predicted to enable bioactive lipid receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within T cell homeostasis. Predicted to be integral component of plasma membrane. Orthologous to human GPR174 (G protein-coupled receptor 174). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 166.1), Thymus (RPKM 131.3) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr174 in Genome Data Viewer
Location:
Xq22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (76428274..76469020)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (72355452..72396146)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (78358347..78399944)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene P2Y receptor family member 10B Neighboring gene prohibitin 1, pseudogene 3 Neighboring gene enolase 1, pseudogene 29 Neighboring gene integral membrane protein 2A Neighboring gene prohibitin 1, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. Barnes MJ, et al. J Exp Med, 2015 Jun 29. PMID 26077720, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bioactive lipid receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 174

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106938.1 → NP_001100408.1  probable G-protein coupled receptor 174

    See identical proteins and their annotated locations for NP_001100408.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473969
    UniProtKB/TrEMBL
    A6IV67, D3ZWS1
    Conserved Domains (1) summary
    cd15152
    Location:20 → 303
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    76428274..76469020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257163.5 → XP_006257225.1  probable G-protein coupled receptor 174 isoform X1

    See identical proteins and their annotated locations for XP_006257225.1

    UniProtKB/TrEMBL
    A6IV67, D3ZWS1
    Related
    ENSRNOP00000044021.3
    Conserved Domains (1) summary
    cd15152
    Location:20 → 303
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006257164.5 → XP_006257226.1  probable G-protein coupled receptor 174 isoform X1

    See identical proteins and their annotated locations for XP_006257226.1

    UniProtKB/TrEMBL
    A6IV67, D3ZWS1
    Conserved Domains (1) summary
    cd15152
    Location:20 → 303
    7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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