hbba1 hemoglobin, beta adult 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hbba1provided by ZNC
Official Full Name: hemoglobin, beta adult 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-18
See related: Ensembl:ENSDARG00000089087 AllianceGenome:ZFIN:ZDB-GENE-990415-18
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ba1; ba2; hbb; ba2l; hbba1.2; zgc:92900; zgc:123164; zgc:136512; si:dZ118J2.3; si:dz118j2.1; si:bY187G17.2
Summary: Predicted to enable oxygen carrier activity. Acts upstream of or within response to hypoxia. Predicted to be part of hemoglobin complex. Is expressed in brain; eye; intermediate cell mass of mesoderm; and vasculature. Human ortholog(s) of this gene implicated in sickle cell anemia. Orthologous to human HBE1 (hemoglobin subunit epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (55103445..55104310, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (54848843..54849708, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

hba1 (e-PCR)
- UniSTS:186966

U50380 (e-PCR)
- UniSTS:205677

fj04a05.x1 (e-PCR)
- UniSTS:198337

Clone Names

MGC63973, MGC73299, MGC92900, MGC123164, MGC136512

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within oxygen transport	IEA Inferred from Electronic Annotation more info
involved_in oxygen transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info
part_of hemoglobin complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hemoglobin subunit beta-1

Names: ba1 globin; ba2 globin; beta-1-globin; beta-2-globin; beta-A1-globin; beta-A2-globin; hemoglobin beta-1 chain; hemoglobin beta-2 chain; hemoglobin subunit beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.