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tle3a TLE family member 3, transcriptional corepressor a [ Danio rerio (zebrafish) ]

Gene ID: 30206, updated on 27-Mar-2024

Summary

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Official Symbol
tle3aprovided by ZNC
Official Full Name
TLE family member 3, transcriptional corepressor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-86
See related
Ensembl:ENSDARG00000002787 AllianceGenome:ZFIN:ZDB-GENE-990415-86
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
grg2; gro2; groucho2; sb:eu295; sb:eu753
Summary
Predicted to enable transcription corepressor activity. Acts upstream of or within regulation of retinoic acid biosynthetic process and sclerotome development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including axis; central nervous system; cranial ganglion; mesoderm; and neural rod. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See tle3a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20225911..20257524)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20236846..20268454)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1 Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats a Neighboring gene kinesin family member 23 Neighboring gene progestin and adipoQ receptor family member Va

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish mitotic kinesin-like protein 1 (Mklp1) functions in embryonic cytokinesis. Chen MC, et al. Physiol Genomics, 2002 Feb 11. PMID 11842131
  2. Two zebrafish homologues of the Drosophila neurogenic gene groucho and their pattern of transcription during early embryogenesis. Wülbeck C, et al. Dev Genes Evol, 1997 Aug. PMID 27747413
  3. Evolution of the Groucho/Tle gene family: gene organization and duplication events. Bajoghli B. Dev Genes Evol, 2007 Aug. PMID 17624551
  4. Duplicated members of the Groucho/Tle gene family in fish. Aghaallaei N, et al. Dev Dyn, 2005 Sep. PMID 16059907
  5. her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development. Takke C, et al. Development, 1999 Jul. PMID 10357943

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of retinoic acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sclerotome development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 3-A; protein groucho-2
Names
groucho-related Grg2
groucho-related protein grg2
transducin-like enhancer of split 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313694.1 → NP_001300623.1  transducin-like enhancer protein 3-A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX324138, CT613405, EH525475
    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M2B5H4, B3DGV3, E7F3V0
    Related
    ENSDARP00000091405.4, ENSDART00000100632.4
    Conserved Domains (5) summary
    COG2319
    Location:468 → 760
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:474 → 759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam15719
    Location:290 → 335
    DUF4674; Domain of unknown function (DUF4674)
    sd00039
    Location:479 → 518
    7WD40; WD40 repeat [structural motif]

  2. NM_131012.2 → NP_571087.2  transducin-like enhancer protein 3-A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in its 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BX324138, CT613405, EH525475
    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M2B607
    Conserved Domains (5) summary
    COG2319
    Location:467 → 759
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:473 → 758
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam15719
    Location:289 → 334
    DUF4674; Domain of unknown function (DUF4674)
    sd00039
    Location:478 → 517
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    20225911..20257524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159039.4 → XP_005159096.1  protein groucho-2 isoform X1

    See identical proteins and their annotated locations for XP_005159096.1

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M2B5H4, B3DGV3, E7F3V0
    Related
    ENSDARP00000045678.7, ENSDART00000045679.9
    Conserved Domains (5) summary
    COG2319
    Location:468 → 760
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:474 → 759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam15719
    Location:290 → 335
    DUF4674; Domain of unknown function (DUF4674)
    sd00039
    Location:479 → 518
    7WD40; WD40 repeat [structural motif]

  2. XM_005159041.4 → XP_005159098.1  protein groucho-2 isoform X2

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M2B607
    Conserved Domains (5) summary
    COG2319
    Location:467 → 759
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:473 → 758
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam15719
    Location:289 → 334
    DUF4674; Domain of unknown function (DUF4674)
    sd00039
    Location:478 → 517
    7WD40; WD40 repeat [structural motif]

  3. XM_017351898.2 → XP_017207387.1  protein groucho-2 isoform X1

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M2B5H4, B3DGV3, E7F3V0
    Conserved Domains (5) summary
    COG2319
    Location:468 → 760
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:474 → 759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam15719
    Location:290 → 335
    DUF4674; Domain of unknown function (DUF4674)
    sd00039
    Location:479 → 518
    7WD40; WD40 repeat [structural motif]

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395339.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    231350..261261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O13166.1 GenPept UniProtKB/Swiss-Prot:O13166

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