ccne1 cyclin E1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ccne1provided by ZNC
Official Full Name: cyclin E1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-168
See related: Ensembl:ENSDARG00000098622 AllianceGenome:ZFIN:ZDB-GENE-980526-168
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ccne; cyce; fa18e07; wu:fa18e07
Summary: Enables kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within cell division and regulation of cell cycle. Predicted to be part of cyclin E1-CDK2 complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Is expressed in anterior axial hypoblast; intestine; nervous system; notochord; and polster. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (46020070..46029879)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (45747704..45757513)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.
Title: Circadian clock regulation of the cell cycle in the zebrafish intestine.

Submit: New GeneRIF Correction

General gene information

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Markers

CYCE (e-PCR)
- UniSTS:205337

cyce (e-PCR)
- UniSTS:205659

fb03e04.y1 (e-PCR)
- UniSTS:189838

fa18e07.s1 (e-PCR)
- UniSTS:202432

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin E1-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G1/S-specific cyclin-E1

Names: cyclin E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130995.1 → NP_571070.1 G1/S-specific cyclin-E1

See identical proteins and their annotated locations for NP_571070.1

Status: PROVISIONAL

Source sequence(s)

X83594

UniProtKB/Swiss-Prot

P47794

UniProtKB/TrEMBL

B2GQF9

Related

ENSDARP00000141259.1, ENSDART00000163991.3

Conserved Domains (2) summary

pfam00134
Location:117 → 244

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:247 → 368

Cyclin_C; Cyclin, C-terminal domain