chrd chordin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chrdprovided by ZNC
Official Full Name: chordinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-33
See related: Ensembl:ENSDARG00000006110 AllianceGenome:ZFIN:ZDB-GENE-990415-33
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: chd; din; fe47d04; wu:fe47d04
Summary: Acts upstream of or within several processes, including embryonic organ development; regionalization; and regulation of BMP signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including anterior neural keel; ectoderm; embryonic structure; median fin; and mesoderm. Orthologous to human CHRD (chordin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (46791702..46828902, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (46557787..46594810, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors found that BMP2b and Chordin diffuse and rapidly form extracellular protein gradients, Chordin does not modulate the diffusivity or distribution of BMP2b, and Chordin is not required to establish peak levels of BMP signaling.
Title: Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd and subsequent maintenance of dkk1b expression levels.
Title: Chordin and dickkopf-1b are essential for the formation of head structures through activation of the FGF signaling pathway in zebrafish.
Binding of CV2 to Chordin promotes BMP-2 signaling.
Title: Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity.
Targeted knockdown of Sox17 and Chd in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty, and heart and pancreas placement in the embryo.
Title: Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish.
Chl, like Chd, dorsalizes embryos upon overexpression and is cleaved by BMP1; loss-of-function experiments show Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd in forming the dorsoventral axis.
Title: Zebrafish chordin-like and chordin are functionally redundant in regulating patterning of the dorsoventral axis.
Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.
Title: A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family.
Chordin expression is required for the 'ciuffo' phenotype and for expression of neural markers when both beta-catenins are inhibited.
Title: Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo.
by regulating the expression of her5, the Bmp2b/Chordin gradient directs the anteroposterior patterning of endoderm in zebrafish embryos
Title: BMP signalling regulates anteroposterior endoderm patterning in zebrafish.
Required both during and after gastrulation for proper patterning of the tail.
Title: Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissues.
specification of anterior neural tissue requires later activities of Chordin and mesodermal factors.
Title: Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

CHORDIN (e-PCR)
- UniSTS:205392

fe47d04.x1 (e-PCR)
- UniSTS:196481

Z6024 (e-PCR)
- UniSTS:204688

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior axis specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within caudal fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal convergence	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otic placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within specification of animal organ position	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chordin

Names: chordino; dino (din); protein chordino

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.