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Stk36 serine/threonine kinase 36 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301516, updated on 13-Apr-2024

Summary

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Official Symbol
Stk36provided by RGD
Official Full Name
serine/threonine kinase 36provided by RGD
Primary source
RGD:1307318
See related
Ensembl:ENSRNOG00000016913 AllianceGenome:RGD:1307318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cilium assembly; positive regulation of hh target transcription factor activity; and positive regulation of smoothened signaling pathway. Predicted to act upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 66.1), Lung (RPKM 29.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q33
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83625905..83652785)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76176922..76204423)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81880175..81908014)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 4 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene uncharacterized LOC134480595 Neighboring gene tubulin tyrosine ligase like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. Maloveryan A, et al. J Cell Commun Signal, 2007 Dec. PMID 18600476, Free PMC Article
  2. Gli regulation by the opposing activities of fused and suppressor of fused. Murone M, et al. Nat Cell Biol, 2000 May. PMID 10806483
  3. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Merchant M, et al. Mol Cell Biol, 2005 Aug. PMID 16055717, Free PMC Article
  4. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Wilson CW, et al. Nature, 2009 May 7. PMID 19305393, Free PMC Article
  5. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 36
Names
serine/threonine kinase 36 (fused homolog, Drosophila)
NP_001167457.1
XP_006245236.1
XP_063123044.1
XP_063123045.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173986.1 → NP_001167457.1  serine/threonine-protein kinase 36

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    D3ZA65
    Related
    ENSRNOP00000022839.7, ENSRNOT00000022839.8
    Conserved Domains (2) summary
    smart00220
    Location:4 → 254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    83625905..83652785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245174.5 → XP_006245236.1  serine/threonine-protein kinase 36 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y8C3, D3ZA65
    Related
    ENSRNOP00000077934.1
    Conserved Domains (2) summary
    smart00220
    Location:4 → 254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

  2. XM_063266974.1 → XP_063123044.1  serine/threonine-protein kinase 36 isoform X2

  3. XM_063266975.1 → XP_063123045.1  serine/threonine-protein kinase 36 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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