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Rnf25 ring finger protein 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301515, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf25provided by RGD
Official Full Name
ring finger protein 25provided by RGD
Primary source
RGD:1311557
See related
Ensembl:ENSRNOG00000016886 AllianceGenome:RGD:1311557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NF-kappaB binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human RNF25 (ring finger protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 113.3), Kidney (RPKM 82.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83619148..83626020, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76170037..76176924, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81873293..81880172, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 4 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene serine/threonine kinase 36 Neighboring gene uncharacterized LOC134480595 Neighboring gene tubulin tyrosine ligase like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. Asamitsu K, et al. J Biol Chem, 2003 Jul 18. PMID 12748188
  2. EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Ding W, et al. Proc Natl Acad Sci U S A, 2008 Sep 9. PMID 18757723, Free PMC Article
  3. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF25
NP_001012004.2
XP_006245234.1
XP_006245235.1
XP_038939286.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012004.2 → NP_001012004.2  E3 ubiquitin-protein ligase RNF25

    See identical proteins and their annotated locations for NP_001012004.2

    Status: VALIDATED

    Source sequence(s)
    BM382839, CB691642, CB775437, CF114855, CK845002
    UniProtKB/TrEMBL
    A6JVV5, D3ZQ26
    Conserved Domains (2) summary
    smart00591
    Location:19 → 127
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam13639
    Location:132 → 197
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    83619148..83626020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245172.5 → XP_006245234.1  E3 ubiquitin-protein ligase RNF25 isoform X1

    UniProtKB/TrEMBL
    D3ZQ26
    Conserved Domains (2) summary
    smart00591
    Location:19 → 127
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam13639
    Location:132 → 196
    zf-RING_2; Ring finger domain

  2. XM_039083358.2 → XP_038939286.1  E3 ubiquitin-protein ligase RNF25 isoform X3

    UniProtKB/TrEMBL
    D3ZQ26
    Related
    ENSRNOP00000022677.6
    Conserved Domains (1) summary
    cd16470
    Location:22 → 87
    RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins

  3. XM_006245173.4 → XP_006245235.1  E3 ubiquitin-protein ligase RNF25 isoform X2

    UniProtKB/TrEMBL
    D3ZQ26
    Conserved Domains (2) summary
    smart00591
    Location:6 → 94
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam13639
    Location:99 → 164
    zf-RING_2; Ring finger domain
Nucleotide Protein Strain
Heading Accession and Version

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