Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndufs1provided by RGD
Official Full Name: NADH:ubiquinone oxidoreductase core subunit S1provided by RGD
Primary source: RGD:1359670
See related: Ensembl:ENSRNOG00000011849 AllianceGenome:RGD:1359670
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity and electron transfer activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in several processes, including mitochondrial electron transport, NADH to ubiquinone; mitochondrion organization; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 2953.4), Muscle (RPKM 1677.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (72040286..72073605, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (64546430..64579751, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (69919863..69953182, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress.
Title: Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress.
A critical postnatal accumulation of oxidatively damaged respiratory complex I occurs in the cerebellum following prenatal exposure to all-trans retinoic acid.
Title: Rat embryo exposure to all-trans retinoic acid results in postnatal oxidative damage of respiratory complex I in the cerebellum.
lower activity in myocardial mitochondria with aging; could be restored by exogenously added cardiolipin
Title: Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin.
the inhibitory effect of alpha-Syn on complex I activity of mitochondrial respiratory chain was also dose-dependent
Title: alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134359 (e-PCR)
- UniSTS:217641

Ndufs1 (e-PCR), detects polymorphism
- UniSTS:527441

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase (ubiquinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
contributes_to NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ATP synthesis coupled electron transport	IEA Inferred from Electronic Annotation more info
involved_in apoptotic mitochondrial changes	ISO Inferred from Sequence Orthology more info
involved_in apoptotic mitochondrial changes	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in cellular respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Names: NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa

NP_001005550.1

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005550.1 → NP_001005550.1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_001005550.1

Status: PROVISIONAL

Source sequence(s)

BC081892

UniProtKB/Swiss-Prot

Q66HF1

UniProtKB/TrEMBL

A0A8I5ZXM3, A6IPF8

Related

ENSRNOP00000087012.1, ENSRNOT00000104288.1

Conserved Domains (1) summary

PRK09130
Location:31 → 723

PRK09130; NADH dehydrogenase subunit G; Validated