wnt1 wingless-type MMTV integration site family, member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wnt1provided by ZNC
Official Full Name: wingless-type MMTV integration site family, member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-526
See related: Ensembl:ENSDARG00000055554 AllianceGenome:ZFIN:ZDB-GENE-980526-526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: WNT-1; int-1; sb:eu647; zgc:194464; zgc:194478
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within brain development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural keel; neural plate; neural rod; and neural tube. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (27651609..27658376)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (27725225..27731712)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the zebrafish, wnt1 and its neighboring paralog, wnt10b, are expressed in largely overlapping patterns, suggesting co-regulation; results suggest that the control of wnt1 and wnt10b expression is under complex regulation involving the interaction of multiple enhancers.
Title: Analysis of the wnt1 regulatory chromosomal landscape.
analysis of differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation
Title: Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Title: Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3.
Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis
Title: Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.
The boundary and roof plate expression of wnt1 each contribute to upregulation of proneural and delta gene expression and neurogenesis in non-boundary regions.
Title: Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain.
novel role for Wnt/beta-catenin signalling in determining endocardial cell fate
Title: The Wnt/beta-catenin pathway regulates cardiac valve formation.
In zebrafish embryos lacking Wnt3a, Wnt1 and Wnt10b, the expression of engrailed orthologs, pax2a and fgf8 is not maintained after mid-somitogenesis
Title: Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formation.
Wnt/Axin/beta-catenin pathway has a role in ventral CNS development
Title: Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity.
two Dvl-associated paralogs, Dpr1 and Dpr2, participate in distinct Wnt-dependent developmental processes
Title: Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes.

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General gene information

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Markers

wnt1 (e-PCR), detects polymorphism
- UniSTS:238179

wnt1 (e-PCR), detects polymorphism
- UniSTS:205470

wnt1 (e-PCR), detects polymorphism
- UniSTS:187049

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebellum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fourth ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-1

Names: etID22400.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201398.1 → NP_001188327.1 protein Wnt-1 precursor

See identical proteins and their annotated locations for NP_001188327.1

Status: VALIDATED

Source sequence(s)

BC163014

UniProtKB/Swiss-Prot

P24257

UniProtKB/TrEMBL

B3DI55

Related

ENSDARP00000072397.2, ENSDART00000077931.3

Conserved Domains (1) summary

smart00097
Location:59 → 370

WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

27651609..27658376

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162223.4 → XP_005162280.1 protein Wnt-1 isoform X1

UniProtKB/TrEMBL

A0A8M2B987

Conserved Domains (1) summary

smart00097
Location:64 → 375

WNT1; found in Wnt-1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_130951.2: Suppressed sequence

Description

NM_130951.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.