foxa2 forkhead box A2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: foxa2provided by ZNC
Official Full Name: forkhead box A2provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-404
See related: Ensembl:ENSDARG00000003411 AllianceGenome:ZFIN:ZDB-GENE-980526-404
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ax; axl; fkd1; HNF-3B; tdsubc_2g8; wu:fe05g04; ik:tdsubc_2g8; xx:tdsubc_2g8
Summary: Enables transcription cis-regulatory region binding activity. Acts upstream of or within axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (42565998..42568438, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (42290592..42293032, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in FoxA2-FoxA3 double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
Title: FoxA transcription factors are essential for the development of dorsal axial structures.
Foxa2 is required for induction and/or patterning of several distinct cell types in the ventral CNS.
Title: Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones.

Submit: New GeneRIF Correction

General gene information

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Markers

Z22762 (e-PCR)
- UniSTS:186930

fe05g04.x1 (e-PCR)
- UniSTS:195996

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axial mesoderm morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system myelin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventral midline development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein A2

Names: axial protein; etID309811.17; hnf3b; mol; monorail

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130949.2 → NP_571024.1 forkhead box protein A2

See identical proteins and their annotated locations for NP_571024.1

Status: PROVISIONAL

Source sequence(s)

Z22762

UniProtKB/Swiss-Prot

Q07342

Related

ENSDARP00000007827.6, ENSDART00000014296.7

Conserved Domains (3) summary

smart00339
Location:151 → 239

FH; FORKHEAD

pfam08430
Location:18 → 150

Forkhead_N; Forkhead N-terminal region

pfam09354
Location:340 → 398

HNF_C; HNF3 C-terminal domain