skib v-ski avian sarcoma viral oncogene homolog b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: skibprovided by ZNC
Official Full Name: v-ski avian sarcoma viral oncogene homolog bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990715-10
See related: Ensembl:ENSDARG00000008034 AllianceGenome:ZFIN:ZDB-GENE-990715-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc17g02; wu:fc17g02; wu:fk79g04
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within cartilage development; dorsal/ventral pattern formation; and heart looping. Located in nucleus. Is expressed in central nervous system. Used to study craniosynostosis. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (25782721..25829708, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (25545105..25592092, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc17g02.x1 (e-PCR)
- UniSTS:203834

fk79g04.x1 (e-PCR)
- UniSTS:201547

fc87g11.x1 (e-PCR)
- UniSTS:188356

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: v-ski avian sarcoma viral oncogene homolog b

Names: nuclear oncoprotein skib

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130938.1 → NP_571013.1 v-ski avian sarcoma viral oncogene homolog b

See identical proteins and their annotated locations for NP_571013.1

Status: PROVISIONAL

Source sequence(s)

AF060118

UniProtKB/TrEMBL

A0A8M1PB01, Q9YI02

Related

ENSDARP00000094325.4, ENSDART00000103549.5

Conserved Domains (2) summary

pfam02437
Location:71 → 169

Ski_Sno; SKI/SNO/DAC family

pfam08782
Location:195 → 288

c-SKI_SMAD_bind; c-SKI Smad4 binding domain