U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ptpn1 protein tyrosine phosphatase non-receptor type 1 [ Danio rerio (zebrafish) ]

Gene ID: 30081, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ptpn1provided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-980605-23
See related
Ensembl:ENSDARG00000007923 AllianceGenome:ZFIN:ZDB-GENE-980605-23
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ptp1b; wu:fk54h03
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in endoplasmic reticulum. Is expressed in liver. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28398780..28408414, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28343616..28359201, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene tyrosine-protein phosphatase non-receptor type 1-like Neighboring gene uncharacterized LOC110439998 Neighboring gene uncharacterized LOC110439999 Neighboring gene uncharacterized LOC110440000

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pleiotropic effects of zebrafish protein-tyrosine phosphatase-1B on early embryonic development. van der Sar AM, et al. Int J Dev Biol, 1999 Nov. PMID 10707902
  2. Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo. Feng CW, et al. Parkinsons Dis, 2020. PMID 33456749, Free PMC Article
  3. VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Lanahan AA, et al. Dev Cell, 2010 May 18. PMID 20434959, Free PMC Article
  4. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Thomas JK, et al. Aquat Toxicol, 2013 Apr 15. PMID 23399444
  5. SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). Studzinski AL, et al. Gen Comp Endocrinol, 2009 Mar. PMID 18955058

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of PERK-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein phosphatase non-receptor type 1
Names
protein tyrosine phosphatase 1b
NP_001300614.1
NP_001300615.1
NP_570999.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313685.1 → NP_001300614.1  tyrosine-protein phosphatase non-receptor type 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC049294, CABZ01087208, Y14427
    UniProtKB/TrEMBL
    A0A8M1P706, Q9PT91
    Related
    ENSDARP00000062692.5, ENSDART00000062693.6
    Conserved Domains (2) summary
    smart00194
    Location:1 → 274
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:41 → 274
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001313686.1 → NP_001300615.1  tyrosine-protein phosphatase non-receptor type 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    CABZ01087208, CABZ01087209
    UniProtKB/TrEMBL
    A0A8M1P706, Q9PT91
    Conserved Domains (2) summary
    smart00194
    Location:1 → 274
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:41 → 274
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  3. NM_130924.3 → NP_570999.2  tyrosine-protein phosphatase non-receptor type 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    CABZ01087208, Y14427
    UniProtKB/TrEMBL
    A0A8M1P706, Q9PT91
    Conserved Domains (2) summary
    smart00194
    Location:1 → 274
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:41 → 274
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    28398780..28408414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous