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cat catalase [ Danio rerio (zebrafish) ]

Gene ID: 30068, updated on 21-Apr-2024

Summary

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Official Symbol
catprovided by ZNC
Official Full Name
catalaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000210-20
See related
Ensembl:ENSDARG00000104702 AllianceGenome:ZFIN:ZDB-GENE-000210-20
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb68a12; wu:fb68a12
Summary
Predicted to enable catalase activity and heme binding activity. Acts upstream of or within response to copper ion. Predicted to be active in mitochondrion and peroxisome. Is expressed in several structures, including digestive system; gill; muscle; retina; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (7492735..7529614)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (7318717..7328379)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene protein regulator of cytokinesis 1a Neighboring gene synaptotagmin XII Neighboring gene interferon induced transmembrane protein 5 Neighboring gene cyclin dependent kinase inhibitor 1Cb Neighboring gene phosphatidylserine synthase 2 Neighboring gene fucokinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The comparison of methods for measuring oxidative stress in zebrafish brains. Moussavi Nik SH, et al. Zebrafish, 2014 Jun. PMID 24798242
  2. Betanodavirus induces oxidative stress-mediated cell death that prevented by anti-oxidants and zfcatalase in fish cells. Chang CW, et al. PLoS One, 2011. PMID 21991373, Free PMC Article
  3. Molecular cloning and sequence analysis of the Danio rerio catalase gene. Gerhard GS, et al. Comp Biochem Physiol B Biochem Mol Biol, 2000 Dec. PMID 11281262
  4. Cloning and expression of a cDNA coding for catalase from zebrafish (Danio rerio). Ken CF, et al. J Agric Food Chem, 2000 Jun. PMID 10888504
  5. Developmental co-exposure of TBBPA and titanium dioxide nanoparticle induced behavioral deficits in larval zebrafish. Chen J, et al. Ecotoxicol Environ Saf, 2021 Jun 1. PMID 33780780

See all (321) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of benzophenone-3 on the integument and gills of zebrafish (Danio rerio).
    Title: Impact of benzophenone-3 on the integument and gills of zebrafish (Danio rerio).
  2. fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1.
    Title: Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
  3. Antioxidants diphenyliodonium and N-acetylcysteine or overexpression of zebrafish catalase in GF-1 cells also reduced ROS production and protected cells for enhancing host survival rate due to red-spotted grouper nervous necrosis virus infection.
    Title: Betanodavirus induces oxidative stress-mediated cell death that prevented by anti-oxidants and zfcatalase in fish cells.
  4. Treatment of light responsive cells with hydrogen peroxide triggers induction of this gene.
    Title: Circadian control by the reduction/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to copper ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
catalase
NP_570987.2
XP_021326116.1
XP_021326117.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130912.2 → NP_570987.2  catalase

    Status: VALIDATED

    Source sequence(s)
    AW421053, BI702391, CABZ01041781, CU694456, DT067765, EB863463, EH495513
    UniProtKB/Swiss-Prot
    Q9I8V5, Q9PT92
    UniProtKB/TrEMBL
    A0A0R4II89, A0A8M1PAV5
    Related
    ENSDARP00000134519.1, ENSDART00000166496.3
    Conserved Domains (1) summary
    cd08156
    Location:68 → 497
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    7492735..7529614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470442.1 → XP_021326117.1  catalase isoform X1

    UniProtKB/Swiss-Prot
    Q9I8V5, Q9PT92
    UniProtKB/TrEMBL
    A0A0R4II89, A0A8M1PAV5
    Conserved Domains (1) summary
    cd08156
    Location:68 → 497
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase

  2. XM_021470441.1 → XP_021326116.1  catalase isoform X1

    UniProtKB/Swiss-Prot
    Q9I8V5, Q9PT92
    UniProtKB/TrEMBL
    A0A0R4II89, A0A8M1PAV5
    Conserved Domains (1) summary
    cd08156
    Location:68 → 497
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PT92.1 GenPept UniProtKB/Swiss-Prot:Q9PT92

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