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Scd3 stearoyl-coenzyme A desaturase 3 [ Mus musculus (house mouse) ]

Gene ID: 30049, updated on 8-Feb-2024

Summary

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Official Symbol
Scd3provided by MGI
Official Full Name
stearoyl-coenzyme A desaturase 3provided by MGI
Primary source
MGI:MGI:1353437
See related
Ensembl:ENSMUSG00000025202 AllianceGenome:MGI:1353437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930513N16Rik
Summary
Enables palmitoyl-CoA 9-desaturase activity. Acts upstream of or within monounsaturated fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to several human genes including SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 90.3), mammary gland adult (RPKM 75.0) and 6 other tissues See more
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Genomic context

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Location:
19 C3; 19 37.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44191727..44232455)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44203288..44244016)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene predicted gene, 52383 Neighboring gene STARR-seq mESC enhancer starr_46220 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2 Neighboring gene polycystic kidney disease 2-like 1 Neighboring gene STARR-seq mESC enhancer starr_46221 Neighboring gene STARR-seq mESC enhancer starr_46222 Neighboring gene STARR-positive B cell enhancer mm9_chr19:44341455-44341756 Neighboring gene stearoyl-coenzyme A desaturase pseudogene Neighboring gene predicted gene, 54046 Neighboring gene predicted gene, 35183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a novel SCD gene and expression of the SCD gene family in mouse skin. Parimoo S, et al. J Investig Dermatol Symp Proc, 1999 Dec. PMID 10674390
  2. Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress. Bond LM, et al. PLoS One, 2018. PMID 30427862, Free PMC Article
  3. UCP1 deficiency increases adipose tissue monounsaturated fatty acid synthesis and trafficking to the liver. Bond LM, et al. J Lipid Res, 2018 Feb. PMID 29203476, Free PMC Article
  4. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Dahlhoff M, et al. Development, 2016 May 15. PMID 26989175
  5. Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Zheng Y, et al. Genomics, 2001 Jan 15. PMID 11161812

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-CoA 9-desaturase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT enables stearoyl-CoA 9-desaturase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables stearoyl-CoA 9-desaturase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monounsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-CoA desaturase 3
Names
delta(9)-desaturase 3
fatty acid desaturase 3
palmitoyl-CoA desaturase
stearoyl-CoA desaturase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024450.2 → NP_077770.1  acyl-CoA desaturase 3

    See identical proteins and their annotated locations for NP_077770.1

    Status: VALIDATED

    Source sequence(s)
    AC123853, AC125101, AF272037
    Consensus CDS
    CCDS29847.1
    UniProtKB/Swiss-Prot
    Q3UWK5, Q99PL7, Q9D550
    UniProtKB/TrEMBL
    Q8BNZ5
    Related
    ENSMUSP00000026220.6, ENSMUST00000026220.7
    Conserved Domains (2) summary
    cd03505
    Location:97 → 337
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:102 → 306
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44191727..44232455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PL7.1 GenPept UniProtKB/Swiss-Prot:Q99PL7

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