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Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300128, updated on 13-Apr-2024

Summary

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Official Symbol
Celsr1provided by RGD
Official Full Name
cadherin, EGF LAG seven-pass G-type receptor 1provided by RGD
Primary source
RGD:1560078
See related
Ensembl:ENSRNOG00000021285 AllianceGenome:RGD:1560078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in cell-cell adhesion and establishment of planar polarity. Predicted to act upstream of or within several processes, including Rho protein signal transduction; apical protein localization; and morphogenesis of an epithelium. Predicted to be located in nucleoplasm and plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 53.4), Lung (RPKM 43.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Celsr1 in Genome Data Viewer
Location:
7q34
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (118867450..119004859, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (116987616..117125035, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (126774010..126914085, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene G-2 and S-phase expressed 1 Neighboring gene tRNA mitochondrial 2-thiouridylase Neighboring gene GRAM domain containing 4 Neighboring gene uncharacterized LOC134479762 Neighboring gene ceramide kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly Through the Wnt/PKC Signaling Pathway. Wang LH, et al. Int J Mol Sci, 2020 Feb 13. PMID 32070035, Free PMC Article
  2. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. Beall SA, et al. J Androl, 2005 Jul-Aug. PMID 15955893
  3. Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curtin JA, et al. Curr Biol, 2003 Jul 1. PMID 12842012
  4. Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. Ravni A, et al. J Invest Dermatol, 2009 Oct. PMID 19357712
  5. Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Formstone CJ, et al. Mol Cell Neurosci, 2010 Jul. PMID 20353824

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly Through the Wnt/PKC Signaling Pathway.
    Title: CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly Through the Wnt/PKC Signaling Pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apical protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of body hair planar orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of planar polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of planar polarity of embryonic epithelium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lateral sprouting involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within motor neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube closure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization involved in establishment of planar polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin EGF LAG seven-pass G-type receptor 1
Names
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
flamingo-like protein celsr1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427591.1 → NP_001414520.1  cadherin EGF LAG seven-pass G-type receptor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    F1MAS4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    118867450..119004859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080317.2 → XP_038936245.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X2

    UniProtKB/TrEMBL
    A6HTF9
    Conserved Domains (13) summary
    smart00303
    Location:2422 → 2475
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:808 → 903
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2067 → 2128
    HormR; Domain present in hormone receptors
    smart00179
    Location:1923 → 1961
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:1889 → 1923
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2017 → 2055
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1459 → 1642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:1951 → 2000
    TNFRSF; CRD3 [structural motif]
    pfam02210
    Location:1734 → 1864
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:2145 → 2396
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:2482 → 2507
    7tm_GPCRs; TM helix 1 [structural motif]
    cl22855
    Location:1930 → 2026
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    cl28897
    Location:2480 → 2733
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_063263331.1 → XP_063119401.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X3

  3. XM_006242167.5 → XP_006242229.1  cadherin EGF LAG seven-pass G-type receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006242229.1

    UniProtKB/TrEMBL
    A6HTF9
    Conserved Domains (10) summary
    smart00303
    Location:2422 → 2475
    GPS; G-protein-coupled receptor proteolytic site domain
    cd11304
    Location:808 → 903
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00008
    Location:2067 → 2128
    HormR; Domain present in hormone receptors
    cd00054
    Location:1889 → 1923
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:2017 → 2055
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1459 → 1642
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00002
    Location:2509 → 2712
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02210
    Location:1734 → 1864
    Laminin_G_2; Laminin G domain
    pfam16489
    Location:2146 → 2394
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl22855
    Location:1930 → 2026
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024251.1: Suppressed sequence

    Description
    NM_001024251.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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