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Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 299976, updated on 11-Apr-2024

Summary

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Official Symbol
Rrm2bprovided by RGD
Official Full Name
ribonucleotide reductase regulatory TP53 inducible subunit M2Bprovided by RGD
Primary source
RGD:1306045
See related
Ensembl:ENSRNOG00000025454 AllianceGenome:RGD:1306045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in response to amine. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 120.9), Kidney (RPKM 112.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (70962008..70993726, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (69077024..69108742, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (76750045..76780817, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene neurocalcin delta Neighboring gene uncharacterized LOC120093633 Neighboring gene uncharacterized LOC134479713 Neighboring gene uncharacterized LOC120093634 Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 Neighboring gene poly(A) polymerase beta, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM). Tudzarova-Trajkovska S, et al. J Cell Biochem, 2003 Nov 1. PMID 14587038
  2. Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Kimura T, et al. Nat Genet, 2003 Aug. PMID 12858174
  3. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Bourdon A, et al. Nat Genet, 2007 Jun. PMID 17486094
  4. Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. Guittet O, et al. J Biol Chem, 2001 Nov 2. PMID 11517226
  5. A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations. Wei X, et al. PLoS Genet, 2014 Dec. PMID 25502805, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within deoxyribonucleoside triphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within renal system process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to amine IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in ribonucleoside diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonucleoside-diphosphate reductase subunit M2 B
Names
ribonucleotide reductase M2 B (TP53 inducible)
NP_001124015.1
XP_038934729.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130543.1 → NP_001124015.1  ribonucleoside-diphosphate reductase subunit M2 B

    See identical proteins and their annotated locations for NP_001124015.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A6HR51, D4ADQ1
    Related
    ENSRNOP00000038047.6, ENSRNOT00000033704.7
    Conserved Domains (1) summary
    cl00264
    Location:32 → 351
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    70962008..70993726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078801.2 → XP_038934729.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACU7
    Related
    ENSRNOP00000090940.1
    Conserved Domains (1) summary
    cl00264
    Location:16 → 299
    Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Nucleotide Protein Strain
Heading Accession and Version

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