U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atp6v1c1 ATPase H+ transporting V1 subunit C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299971, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Atp6v1c1provided by RGD
Official Full Name
ATPase H+ transporting V1 subunit C1provided by RGD
Primary source
RGD:1311082
See related
Ensembl:ENSRNOG00000004846 AllianceGenome:RGD:1311082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Located in apical part of cell; cytoplasmic vesicle; and plasma membrane. Orthologous to human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 614.4), Kidney (RPKM 396.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (71719326..71757191)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (69834464..69872278)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (77678853..77716658)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093641 Neighboring gene uncharacterized LOC102550582 Neighboring gene uncharacterized LOC134479714 Neighboring gene BAALC binder of MAP3K1 and KLF4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of ATP6V1C1 during oral carcinogenesis. Oliveira Alves MG, et al. Biotech Histochem, 2016. PMID 26984774
  2. A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients. Cheng L, et al. Genomics, 2013 Oct. PMID 23722107
  3. Functional expression of V-ATPases in the plasma membrane of glial cells. Philippe JM, et al. Glia, 2002 Mar 15. PMID 11870875
  4. Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis. Feng S, et al. Int J Biol Sci, 2013. PMID 24155661, Free PMC Article
  5. Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis. Pietrement C, et al. Biol Reprod, 2006 Jan. PMID 16192400

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC109315

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle lumen acidification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
  
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in extrinsic component of synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in extrinsic component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting V-type ATPase, V1 domain ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
V-type proton ATPase subunit C 1
Names
ATPase, H+ transporting, V1 subunit C
ATPase, H+ transporting, lysosomal V1 subunit C1
V-ATPase subunit C 1
vacuolar proton pump subunit C 1
NP_001011992.1
XP_006241664.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011992.1 → NP_001011992.1  V-type proton ATPase subunit C 1

    See identical proteins and their annotated locations for NP_001011992.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089961
    UniProtKB/Swiss-Prot
    Q5FVI6
    UniProtKB/TrEMBL
    A0A8I5Y7J1
    Related
    ENSRNOP00000006917.4, ENSRNOT00000006917.6
    Conserved Domains (2) summary
    cd14785
    Location:56 → 76
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 370
    V-ATPase_C; V-ATPase subunit C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    71719326..71757191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241602.5 → XP_006241664.1  V-type proton ATPase subunit C 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y7J1, A0A8I6GCD8
    Related
    ENSRNOP00000085031.1
    Conserved Domains (2) summary
    cd14785
    Location:56 → 76
    V-ATPase_C; 3-helical coiled coil [structural motif]
    pfam03223
    Location:5 → 337
    V-ATPase_C; V-ATPase subunit C

RNA

  1. XR_010052959.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVI6.1 GenPept UniProtKB/Swiss-Prot:Q5FVI6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous