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Polrmt RNA polymerase mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 299604, updated on 11-Apr-2024

Summary

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Official Symbol
Polrmtprovided by RGD
Official Full Name
RNA polymerase mitochondrialprovided by RGD
Primary source
RGD:1304599
See related
Ensembl:ENSRNOG00000024879 AllianceGenome:RGD:1304599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-directed 5'-3' RNA polymerase activity and mitochondrial promoter sequence-specific DNA binding activity. Predicted to be involved in mitochondrial transcription. Predicted to be located in mitochondrial nucleoid. Predicted to be part of mitochondrial DNA-directed RNA polymerase complex. Orthologous to human POLRMT (RNA polymerase mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 70.0), Heart (RPKM 69.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10610149..10620411)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9959532..9969791)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12840907..12851153)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 126 Neighboring gene fibroblast growth factor 22 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC134479816 Neighboring gene basigin (Ok blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. Wang Z, et al. J Biol Chem, 2007 Apr 27. PMID 17337445, Free PMC Article
  2. TEFM (c17orf42) is necessary for transcription of human mtDNA. Minczuk M, et al. Nucleic Acids Res, 2011 May. PMID 21278163, Free PMC Article
  3. Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Celestini V, et al. Cell Death Dis, 2018 Feb 14. PMID 29445193, Free PMC Article
  4. A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Peserico A, et al. Cell Mol Life Sci, 2013 Jun. PMID 23283301
  5. The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA primase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed 5'-3' RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables mitochondrial promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at mitochondrial promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of mitochondrial DNA-directed RNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase, mitochondrial
Names
polymerase (RNA) mitochondrial (DNA directed)
NP_001100236.1
XP_006240921.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106766.1 → NP_001100236.1  DNA-directed RNA polymerase, mitochondrial

    See identical proteins and their annotated locations for NP_001100236.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474029
    UniProtKB/TrEMBL
    A6K8X9, D3ZYB6
    Related
    ENSRNOP00000032448.6, ENSRNOT00000039232.6
    Conserved Domains (4) summary
    TIGR02223
    Location:22 → 164
    ftsN; cell division protein FtsN
    sd00004
    Location:198 → 225
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:800 → 1202
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:390 → 672
    RPOL_N; DNA-directed RNA polymerase N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10610149..10620411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240859.5 → XP_006240921.1  DNA-directed RNA polymerase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    D3ZYB6
    Conserved Domains (4) summary
    TIGR02223
    Location:22 → 164
    ftsN; cell division protein FtsN
    sd00004
    Location:198 → 225
    PPR; PPR repeat [structural motif]
    pfam00940
    Location:801 → 1203
    RNA_pol; DNA-dependent RNA polymerase
    pfam14700
    Location:391 → 673
    RPOL_N; DNA-directed RNA polymerase N-terminal
Nucleotide Protein Strain
Heading Accession and Version

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