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Mterf3 mitochondrial transcription termination factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299514, updated on 5-Mar-2024

Summary

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Official Symbol
Mterf3provided by RGD
Official Full Name
mitochondrial transcription termination factor 3provided by RGD
Primary source
RGD:735158
See related
Ensembl:ENSRNOG00000004492 AllianceGenome:RGD:735158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cgi12; Mterfd1
Summary
Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in mitochondrial ribosome assembly and negative regulation of transcription, DNA-templated. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human MTERF3 (mitochondrial transcription termination factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 139.6), Adrenal (RPKM 119.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65711654..65729926, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63826418..63844747, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (71275544..71293842, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549197 Neighboring gene ubiquinol-cytochrome c reductase binding protein Neighboring gene 5S ribosomal RNA Neighboring gene phosphatidylserine synthase 1 Neighboring gene establishment of cohesion 1 homolog 2 (S. cerevisiae), pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MTERF3 is a negative regulator of mammalian mtDNA transcription. Park CB, et al. Cell, 2007 Jul 27. PMID 17662942
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC72611

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transcription termination factor 3, mitochondrial
Names
MTERF domain containing 1
mTERF domain-containing protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199387.1 → NP_955419.1  transcription termination factor 3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_955419.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062080
    UniProtKB/Swiss-Prot
    Q6P6Q6
    UniProtKB/TrEMBL
    A6HQY0
    Related
    ENSRNOP00000006185.5, ENSRNOT00000006185.7
    Conserved Domains (1) summary
    cl19765
    Location:145 → 390
    mTERF

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    65711654..65729926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241509.5 → XP_006241571.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:151 → 284
    mTERF; mTERF

  2. XM_063263148.1 → XP_063119218.1  transcription termination factor 3, mitochondrial isoform X3

  3. XM_039078623.2 → XP_038934551.1  transcription termination factor 3, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl19765
    Location:22 → 242
    mTERF
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6Q6.1 GenPept UniProtKB/Swiss-Prot:Q6P6Q6

Gene LinkOut

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