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GPR132 G protein-coupled receptor 132 [ Homo sapiens (human) ]

Gene ID: 29933, updated on 5-Mar-2024

Summary

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Official Symbol
GPR132provided by HGNC
Official Full Name
G protein-coupled receptor 132provided by HGNC
Primary source
HGNC:HGNC:17482
See related
Ensembl:ENSG00000183484 MIM:606167; AllianceGenome:HGNC:17482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G2A
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in appendix (RPKM 4.0), lymph node (RPKM 3.6) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
14q32.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105049395..105065430, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99293953..99309986, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105515732..105531767, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6209 Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105485485-105486145 Neighboring gene H3K27ac hESC enhancers GRCh37_chr14:105486597-105487112 and GRCh37_chr14:105487627-105488140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9128 Neighboring gene Sharpr-MPRA regulatory region 5751 Neighboring gene cell division cycle associated 4 Neighboring gene uncharacterized LOC124903398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105499947-105500448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105521947-105522722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105532273-105532790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9138 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:105536095-105537294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105544057-105544557 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:105544918-105545868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105560015-105560637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9140 Neighboring gene long intergenic non-protein coding RNA 2298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105585919-105586418 Neighboring gene jagged canonical Notch ligand 2 Neighboring gene microRNA 6765

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Ellison MA, et al. Curr Pharm Des, 2012. PMID 22621271, Free PMC Article
  2. Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs. Khan SY, et al. Biochem J, 2010 Nov 15. PMID 20799926, Free PMC Article
  3. Identification and analysis of two splice variants of human G2A generated by alternative splicing. Ogawa A, et al. J Pharmacol Exp Ther, 2010 Feb. PMID 19855098
  4. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. Peter C, et al. J Biol Chem, 2008 Feb 29. PMID 18089568
  5. G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid. Hattori T, et al. J Invest Dermatol, 2008 May. PMID 18034171

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
    Title: Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
  2. Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
    Title: Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
  3. Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
    Title: Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
  4. G protein-coupled receptor 132 (Gpr132) functions as a key macrophage sensor of the rising lactate in the acidic tumor milieu to mediate the reciprocal interaction between cancer cells and macrophages during breast cancer metastasis. Lactate activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migration, and invasion.
    Title: Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
  5. High GPR132 expression is associated with acute lymphoblastic leukemia.
    Title: Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia.
  6. coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced
    Title: Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals.
  7. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
    Title: Integrative predictive model of coronary artery calcification in atherosclerosis.
  8. we found an additional novel G2A variant (G2A-b) that is the major transcript with functional response to ligand stimulation as well as G2A-a, and succeeded in discriminating proton-sensing and oxidized fatty acid-sensing activities of G2A.
    Title: Identification and analysis of two splice variants of human G2A generated by alternative splicing.
  9. 9-HODE-G2A signaling plays proinflammatory roles in skin under oxidative conditions
    Title: G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid.
  10. the G-protein-coupled receptor G2A, unlike its relative GPR4, is involved in the chemotaxis of monocytic cells.
    Title: Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Potential readthrough

Included gene: CDCA4

Homology

Clone Names

  • MGC99642

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 132
Names
G2 accumulation protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278694.2 → NP_001265623.1  probable G-protein coupled receptor 132 isoform 1

    See identical proteins and their annotated locations for NP_001265623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK292142, BC084546
    Consensus CDS
    CCDS9997.1
    UniProtKB/Swiss-Prot
    A8K7X7, B4E144, Q9BSU2, Q9UNW8
    UniProtKB/TrEMBL
    B2LM89
    Related
    ENSP00000438094.2, ENST00000539291.6
    Conserved Domains (1) summary
    cd15364
    Location:43 → 319
    7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001278695.2 → NP_001265624.1  probable G-protein coupled receptor 132 isoform 2

    See identical proteins and their annotated locations for NP_001265624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA714520, AB465600
    Consensus CDS
    CCDS61567.1
    UniProtKB/TrEMBL
    B2LM89
    Related
    ENSP00000376364.2, ENST00000392585.2
    Conserved Domains (1) summary
    pfam00001
    Location:85 → 299
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_001278696.2 → NP_001265625.1  probable G-protein coupled receptor 132 isoform 3

    See identical proteins and their annotated locations for NP_001265625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC084546, DB137292
    UniProtKB/Swiss-Prot
    Q9UNW8
    Conserved Domains (1) summary
    pfam00001
    Location:16 → 120
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. NM_013345.4 → NP_037477.1  probable G-protein coupled receptor 132 isoform 1

    See identical proteins and their annotated locations for NP_037477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA714520, AB465599
    Consensus CDS
    CCDS9997.1
    UniProtKB/Swiss-Prot
    A8K7X7, B4E144, Q9BSU2, Q9UNW8
    UniProtKB/TrEMBL
    B2LM89
    Related
    ENSP00000328818.3, ENST00000329797.8
    Conserved Domains (1) summary
    cd15364
    Location:43 → 319
    7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105049395..105065430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    99293953..99309986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UNW8.1 GenPept UniProtKB/Swiss-Prot:Q9UNW8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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