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Gpr65 G-protein coupled receptor 65 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299242, updated on 13-Apr-2024

Summary

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Official Symbol
Gpr65provided by RGD
Official Full Name
G-protein coupled receptor 65provided by RGD
Primary source
RGD:1311832
See related
Ensembl:ENSRNOG00000065590 AllianceGenome:RGD:1311832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tdag8
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; activation of GTPase activity; and positive regulation of Rho protein signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR65 (G protein-coupled receptor 65). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 102.0), Thymus (RPKM 89.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123245534..123262758)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (117515786..117536514)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122248528..122256115)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cofilin 1, pseudogene 1 Neighboring gene uncharacterized LOC120093266 Neighboring gene galactosylceramidase Neighboring gene uncharacterized LOC120103597 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats. Ma XD, et al. Exp Neurol, 2017 Jul. PMID 28365474
  2. Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain. McGuire J, et al. Biochem Biophys Res Commun, 2009 Aug 28. PMID 19501050, Free PMC Article
  3. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. Ishii S, et al. J Biol Chem, 2005 Mar 11. PMID 15618224
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to acidic pH ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
psychosine receptor
Names
T cell death associated protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106751.3 → NP_001100221.1  psychosine receptor

    See identical proteins and their annotated locations for NP_001100221.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AHC6, B0YIR8
    Conserved Domains (2) summary
    cd14964
    Location:17 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 301
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    123245534..123262758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112062.2 → XP_038967990.1  psychosine receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHC6, B0YIR8
    Conserved Domains (2) summary
    cd14964
    Location:17 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 301
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_008764761.4 → XP_008762983.1  psychosine receptor isoform X1

    See identical proteins and their annotated locations for XP_008762983.1

    UniProtKB/TrEMBL
    A0A8I6AHC6, B0YIR8
    Related
    ENSRNOP00000078802.1
    Conserved Domains (2) summary
    cd14964
    Location:17 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 301
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_039112061.2 → XP_038967989.1  psychosine receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHC6, B0YIR8
    Related
    ENSRNOP00000094255.1
    Conserved Domains (2) summary
    cd14964
    Location:17 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 301
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_039112063.2 → XP_038967991.1  psychosine receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHC6, B0YIR8
    Conserved Domains (2) summary
    cd14964
    Location:17 → 44
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:17 → 301
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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